Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction
The field of drug discovery has seen significant progress in recent years. These advances drive the development of new technologies for testing compound’s effectiveness, as well as their adverse effects on organs and tissues. As an auxiliary tool for drug discovery, smart biomaterials and biopolymer...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/21/4755 |
| _version_ | 1797466647228841984 |
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| author | Liana Chafran Amy Carfagno Amaal Altalhi Barney Bishop |
| author_facet | Liana Chafran Amy Carfagno Amaal Altalhi Barney Bishop |
| author_sort | Liana Chafran |
| collection | DOAJ |
| description | The field of drug discovery has seen significant progress in recent years. These advances drive the development of new technologies for testing compound’s effectiveness, as well as their adverse effects on organs and tissues. As an auxiliary tool for drug discovery, smart biomaterials and biopolymers produced from biodegradable monomers allow the manufacture of multifunctional polymeric devices capable of acting as biosensors, of incorporating bioactives and biomolecules, or even mimicking organs and tissues through self-association and organization between cells and biopolymers. This review discusses in detail the use of natural monomers for the synthesis of hydrogels via green routes. The physical, chemical and morphological characteristics of these polymers are described, in addition to emphasizing polymer–particle–protein interactions and their application in proteomics studies. To highlight the diversity of green synthesis methodologies and the properties of the final hydrogels, applications in the areas of drug delivery, antibody interactions, cancer therapy, imaging and biomarker analysis are also discussed, as well as the use of hydrogels for the discovery of antimicrobial and antiviral peptides with therapeutic potential. |
| first_indexed | 2024-03-09T18:42:40Z |
| format | Article |
| id | doaj.art-0da45defe3f4466ea0ba1a9dbc05f98f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T18:42:40Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-0da45defe3f4466ea0ba1a9dbc05f98f2023-11-24T06:31:22ZengMDPI AGPolymers2073-43602022-11-011421475510.3390/polym14214755Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein InteractionLiana Chafran0Amy Carfagno1Amaal Altalhi2Barney Bishop3Department of Chemistry and Biochemistry, George Mason University, Manassas, VA 20110 , USADepartment of Chemistry and Biochemistry, George Mason University, Manassas, VA 20110 , USADepartment of Chemistry and Biochemistry, George Mason University, Manassas, VA 20110 , USADepartment of Chemistry and Biochemistry, George Mason University, Manassas, VA 20110 , USAThe field of drug discovery has seen significant progress in recent years. These advances drive the development of new technologies for testing compound’s effectiveness, as well as their adverse effects on organs and tissues. As an auxiliary tool for drug discovery, smart biomaterials and biopolymers produced from biodegradable monomers allow the manufacture of multifunctional polymeric devices capable of acting as biosensors, of incorporating bioactives and biomolecules, or even mimicking organs and tissues through self-association and organization between cells and biopolymers. This review discusses in detail the use of natural monomers for the synthesis of hydrogels via green routes. The physical, chemical and morphological characteristics of these polymers are described, in addition to emphasizing polymer–particle–protein interactions and their application in proteomics studies. To highlight the diversity of green synthesis methodologies and the properties of the final hydrogels, applications in the areas of drug delivery, antibody interactions, cancer therapy, imaging and biomarker analysis are also discussed, as well as the use of hydrogels for the discovery of antimicrobial and antiviral peptides with therapeutic potential.https://www.mdpi.com/2073-4360/14/21/4755green synthesishydrogelbiomaterialsproteomicsdrug discovery |
| spellingShingle | Liana Chafran Amy Carfagno Amaal Altalhi Barney Bishop Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction Polymers green synthesis hydrogel biomaterials proteomics drug discovery |
| title | Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction |
| title_full | Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction |
| title_fullStr | Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction |
| title_full_unstemmed | Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction |
| title_short | Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction |
| title_sort | green hydrogel synthesis emphasis on proteomics and polymer particle protein interaction |
| topic | green synthesis hydrogel biomaterials proteomics drug discovery |
| url | https://www.mdpi.com/2073-4360/14/21/4755 |
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