Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women
Introduction: Gestational diabetes is the most common medical condition in pregnancy. Since probiotics are viable microorganisms which have beneficial effects on microbial flora of the intestine, they affect glucose metabolism. Therefore, this study was performed with aim to determine the effect of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Mashhad University of Medical Sciences
2020-04-01
|
| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| Subjects: | |
| Online Access: | https://ijogi.mums.ac.ir/article_15964_1be6f15b42ded37db451ea4cc5fa6f9a.pdf |
| _version_ | 1798044545306329088 |
|---|---|
| author | Mahdieh Ebrahimzadeh Samira Ebrahimzadeh Zagami Masoumeh Kordi Mohmmad Taghi Shakeri Seyed Ahmad Emami Farideh Akhlaghi |
| author_facet | Mahdieh Ebrahimzadeh Samira Ebrahimzadeh Zagami Masoumeh Kordi Mohmmad Taghi Shakeri Seyed Ahmad Emami Farideh Akhlaghi |
| author_sort | Mahdieh Ebrahimzadeh |
| collection | DOAJ |
| description | Introduction: Gestational diabetes is the most common medical condition in pregnancy. Since probiotics are viable microorganisms which have beneficial effects on microbial flora of the intestine, they affect glucose metabolism. Therefore, this study was performed with aim to determine the effect of probiotic capsule on the prevention of gestational diabetes in high risk pre-diabetes pregnant women.
Methods: This double-blind clinical trial study was performed on 255 high risk pre-diabetic pregnant women in health centers covered by health center No.2 of Mashhad in 2018. In the probiotic group and the placebo group, in addition to routine care, one probiotic capsule and placebo were daily prescribed respectively from 14-16 weeks of gestation for 12 weeks. Then, glucose tolerance test (OGTT) was performed at week 26-28. The research tools included demographic and midwifery information form, checklist of pregnancy diabetes screening tests, drug use checklist, examination form and satisfaction form. Data were analyzed using SPSS software (version 22), and Chi-square, One-way ANOVA, Kruskal – Wallis and Mann-Whitney tests. P<0.05 was considered statistically significant.
Results: 21 patients (26.3%) in the probiotic group, 49 (59.8%) in the placebo group, and 55 (67.1%) in the control group had gestational diabetes (P<0.001). Gestational diabetes in the intervention group was significantly less than the placebo and control group. The results of the Chi-square Pearson test for two by two comparison of the groups showed significant difference in gestational diabetes mellitus between probiotic group with placebo (P <0.001) and probiotic group with control (P <0.001). Gestational diabetes in the intervention group in significance level of lower than 5% was lower than the placebo and control group.
Conclusion: The use of probiotic capsules can be recommended to high risk pregnant women in preventing gestational diabetes. |
| first_indexed | 2024-04-11T23:05:53Z |
| format | Article |
| id | doaj.art-0da46c648eab4f23b5443f21c7af9922 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T23:05:53Z |
| publishDate | 2020-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-0da46c648eab4f23b5443f21c7af99222022-12-22T03:58:00ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632020-04-01232576610.22038/ijogi.2020.1596415964Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant womenMahdieh Ebrahimzadeh0Samira Ebrahimzadeh Zagami1Masoumeh Kordi2Mohmmad Taghi Shakeri3Seyed Ahmad Emami4Farideh Akhlaghi5M.Sc. in Midwifery Training, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Epidemiology & Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Traditional Pharmacology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Gestational diabetes is the most common medical condition in pregnancy. Since probiotics are viable microorganisms which have beneficial effects on microbial flora of the intestine, they affect glucose metabolism. Therefore, this study was performed with aim to determine the effect of probiotic capsule on the prevention of gestational diabetes in high risk pre-diabetes pregnant women. Methods: This double-blind clinical trial study was performed on 255 high risk pre-diabetic pregnant women in health centers covered by health center No.2 of Mashhad in 2018. In the probiotic group and the placebo group, in addition to routine care, one probiotic capsule and placebo were daily prescribed respectively from 14-16 weeks of gestation for 12 weeks. Then, glucose tolerance test (OGTT) was performed at week 26-28. The research tools included demographic and midwifery information form, checklist of pregnancy diabetes screening tests, drug use checklist, examination form and satisfaction form. Data were analyzed using SPSS software (version 22), and Chi-square, One-way ANOVA, Kruskal – Wallis and Mann-Whitney tests. P<0.05 was considered statistically significant. Results: 21 patients (26.3%) in the probiotic group, 49 (59.8%) in the placebo group, and 55 (67.1%) in the control group had gestational diabetes (P<0.001). Gestational diabetes in the intervention group was significantly less than the placebo and control group. The results of the Chi-square Pearson test for two by two comparison of the groups showed significant difference in gestational diabetes mellitus between probiotic group with placebo (P <0.001) and probiotic group with control (P <0.001). Gestational diabetes in the intervention group in significance level of lower than 5% was lower than the placebo and control group. Conclusion: The use of probiotic capsules can be recommended to high risk pregnant women in preventing gestational diabetes.https://ijogi.mums.ac.ir/article_15964_1be6f15b42ded37db451ea4cc5fa6f9a.pdfgestational diabetesprediabeticpreventionprobiotic |
| spellingShingle | Mahdieh Ebrahimzadeh Samira Ebrahimzadeh Zagami Masoumeh Kordi Mohmmad Taghi Shakeri Seyed Ahmad Emami Farideh Akhlaghi Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān gestational diabetes prediabetic prevention probiotic |
| title | Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women |
| title_full | Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women |
| title_fullStr | Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women |
| title_full_unstemmed | Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women |
| title_short | Effect of probiotic capsules on preventing gestational diabetes among high-risk prediabetic pregnant women |
| title_sort | effect of probiotic capsules on preventing gestational diabetes among high risk prediabetic pregnant women |
| topic | gestational diabetes prediabetic prevention probiotic |
| url | https://ijogi.mums.ac.ir/article_15964_1be6f15b42ded37db451ea4cc5fa6f9a.pdf |
| work_keys_str_mv | AT mahdiehebrahimzadeh effectofprobioticcapsulesonpreventinggestationaldiabetesamonghighriskprediabeticpregnantwomen AT samiraebrahimzadehzagami effectofprobioticcapsulesonpreventinggestationaldiabetesamonghighriskprediabeticpregnantwomen AT masoumehkordi effectofprobioticcapsulesonpreventinggestationaldiabetesamonghighriskprediabeticpregnantwomen AT mohmmadtaghishakeri effectofprobioticcapsulesonpreventinggestationaldiabetesamonghighriskprediabeticpregnantwomen AT seyedahmademami effectofprobioticcapsulesonpreventinggestationaldiabetesamonghighriskprediabeticpregnantwomen AT faridehakhlaghi effectofprobioticcapsulesonpreventinggestationaldiabetesamonghighriskprediabeticpregnantwomen |