Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation
In pediatric cancer, the overall 5-year survival has increased to more than 80%, but these improvements in cancer outcomes have come at the cost of increased morbidity and mortality. These can occur during or early after treatment, and in others may occur many years after cancer treatment is complet...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of the Practice of Cardiovascular Sciences |
| Subjects: | |
| Online Access: | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2017;volume=3;issue=2;spage=82;epage=93;aulast=Purkayastha |
| _version_ | 1811268757838888960 |
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| author | K Purkayastha Rachna Seth Sandeep Seth Alex R Lyon |
| author_facet | K Purkayastha Rachna Seth Sandeep Seth Alex R Lyon |
| author_sort | K Purkayastha |
| collection | DOAJ |
| description | In pediatric cancer, the overall 5-year survival has increased to more than 80%, but these improvements in cancer outcomes have come at the cost of increased morbidity and mortality. These can occur during or early after treatment, and in others may occur many years after cancer treatment is completed. Survivors of childhood cancers are at an increased risk of developing congestive heart failure and premature death due to cardiac causes (coronary artery disease, stroke, and congestive heart failure). There is a strong dose-dependent relationship between anthracycline chemotherapy exposure and risk of congestive heart failure, and the risk is increased in those who have been exposed to chest radiation. Early detection of myocardial injury, prevention of myocardial dysfunction, strategies to promote quick recovery of myocardial function in case of injury, and monitoring for delayed effects of cancer therapy are areas which both oncologists as well as cardiologists looking after cancer patients need to understand. A subspecialty of cardio-oncology has emerged to allow more focus in these areas. |
| first_indexed | 2024-04-12T21:28:39Z |
| format | Article |
| id | doaj.art-0da52dfbb4dc49e8b2b40effa108a827 |
| institution | Directory Open Access Journal |
| issn | 2395-5414 2454-2830 |
| language | English |
| last_indexed | 2024-04-12T21:28:39Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Practice of Cardiovascular Sciences |
| spelling | doaj.art-0da52dfbb4dc49e8b2b40effa108a8272022-12-22T03:16:05ZengWolters Kluwer Medknow PublicationsJournal of the Practice of Cardiovascular Sciences2395-54142454-28302017-01-0132829310.4103/jpcs.jpcs_33_17Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluationK PurkayasthaRachna SethSandeep SethAlex R LyonIn pediatric cancer, the overall 5-year survival has increased to more than 80%, but these improvements in cancer outcomes have come at the cost of increased morbidity and mortality. These can occur during or early after treatment, and in others may occur many years after cancer treatment is completed. Survivors of childhood cancers are at an increased risk of developing congestive heart failure and premature death due to cardiac causes (coronary artery disease, stroke, and congestive heart failure). There is a strong dose-dependent relationship between anthracycline chemotherapy exposure and risk of congestive heart failure, and the risk is increased in those who have been exposed to chest radiation. Early detection of myocardial injury, prevention of myocardial dysfunction, strategies to promote quick recovery of myocardial function in case of injury, and monitoring for delayed effects of cancer therapy are areas which both oncologists as well as cardiologists looking after cancer patients need to understand. A subspecialty of cardio-oncology has emerged to allow more focus in these areas.http://www.j-pcs.org/article.asp?issn=2395-5414;year=2017;volume=3;issue=2;spage=82;epage=93;aulast=PurkayasthaCardio-oncologycardiotoxicitychemotherapychildhood cancer |
| spellingShingle | K Purkayastha Rachna Seth Sandeep Seth Alex R Lyon Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation Journal of the Practice of Cardiovascular Sciences Cardio-oncology cardiotoxicity chemotherapy childhood cancer |
| title | Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation |
| title_full | Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation |
| title_fullStr | Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation |
| title_full_unstemmed | Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation |
| title_short | Cancer therapy-induced cardiotoxicity: Review and algorithmic approach toward evaluation |
| title_sort | cancer therapy induced cardiotoxicity review and algorithmic approach toward evaluation |
| topic | Cardio-oncology cardiotoxicity chemotherapy childhood cancer |
| url | http://www.j-pcs.org/article.asp?issn=2395-5414;year=2017;volume=3;issue=2;spage=82;epage=93;aulast=Purkayastha |
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