Brain structural alterations in autism and criminal psychopathy
The goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopat...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222001814 |
| _version_ | 1828785135312437248 |
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| author | Tuomo Noppari Lihua Sun Lasse Lukkarinen Vesa Putkinen Pekka Tani Nina Lindberg Emma Saure Hannu Lauerma Jari Tiihonen Niina Venetjoki Marja Salomaa Päivi Rautio Jussi Hirvonen Juha Salmi Lauri Nummenmaa |
| author_facet | Tuomo Noppari Lihua Sun Lasse Lukkarinen Vesa Putkinen Pekka Tani Nina Lindberg Emma Saure Hannu Lauerma Jari Tiihonen Niina Venetjoki Marja Salomaa Päivi Rautio Jussi Hirvonen Juha Salmi Lauri Nummenmaa |
| author_sort | Tuomo Noppari |
| collection | DOAJ |
| description | The goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopathic traits, and 19 control participants using voxel-based morphometry (VBM). Our earlier study showed lower grey matter volume (GMV) values in the insula, frontal cortex, and sensorimotor cortex of the offender group compared to controls. In the present study, the images of the ASD group revealed lower GMV in the left precuneus, right cerebellum, and right precentral gyrus in comparison with controls. The comparison between the offender and ASD groups showed lower GMV values for the right temporal pole and left inferior frontal gyrus in the offender group. There was also an overlap of both disorders in the right pre-central cortex, showing lower GMV compared to controls. Our findings suggest structural differences between violent offenders with high psychopathy traits and ASD individuals in the frontotemporal social brain network areas, previously associated with empathy. We also provide evidence of similar abnormal structures in the motor cortex for both of these disorders, possibly related to uniting issues of social cognition. |
| first_indexed | 2024-12-11T23:45:26Z |
| format | Article |
| id | doaj.art-0da7c0f7983b4e4d8e86d922098ae3cf |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-11T23:45:26Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-0da7c0f7983b4e4d8e86d922098ae3cf2022-12-22T00:45:37ZengElsevierNeuroImage: Clinical2213-15822022-01-0135103116Brain structural alterations in autism and criminal psychopathyTuomo Noppari0Lihua Sun1Lasse Lukkarinen2Vesa Putkinen3Pekka Tani4Nina Lindberg5Emma Saure6Hannu Lauerma7Jari Tiihonen8Niina Venetjoki9Marja Salomaa10Päivi Rautio11Jussi Hirvonen12Juha Salmi13Lauri Nummenmaa14Turku PET Centre, University of Turku, Turku, Finland; Department of Psychiatry, Helsinki University Hospital, Helsinki, Finland; Corrensponding author at: Department of Psychiatry, Helsinki University Hospital, PL, 590, 00029 HUS, Helsinki, Finland.Turku PET Centre, University of Turku, Turku, Finland; Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaTurku PET Centre, University of Turku, Turku, FinlandTurku PET Centre, University of Turku, Turku, FinlandDepartment of Psychiatry, Helsinki University Hospital, Helsinki, FinlandDepartment of Forensic Psychiatry, Helsinki University Hospital, Helsinki, FinlandDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; BABA Center and Department of Clinical Neurophysiology, Children’s Hospital, Helsinki University Hospital and University of Helsinki, FinlandPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, Finland; Department of Forensic Psychiatry, Turku University Central Hospital, FinlandDepartment of Clinical Neuroscience, Karolinska Institute and Center for Psychiatry Research, Stockholm, Sweden; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Neuroscience Center, University of Helsinki, Helsinki, FinlandPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, FinlandPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, FinlandPsychiatric Hospital for Prisoners, Health Care Services for Prisoners, Turku, FinlandDepartment of Radiology, Turku University Hospital, Turku, FinlandDepartment of Neuroscience and Biomedical Engineering, School of Science, Aalto University, Espoo, FinlandTurku PET Centre, University of Turku, Turku, Finland; Department of Psychology, University of Turku, Turku, FinlandThe goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopathic traits, and 19 control participants using voxel-based morphometry (VBM). Our earlier study showed lower grey matter volume (GMV) values in the insula, frontal cortex, and sensorimotor cortex of the offender group compared to controls. In the present study, the images of the ASD group revealed lower GMV in the left precuneus, right cerebellum, and right precentral gyrus in comparison with controls. The comparison between the offender and ASD groups showed lower GMV values for the right temporal pole and left inferior frontal gyrus in the offender group. There was also an overlap of both disorders in the right pre-central cortex, showing lower GMV compared to controls. Our findings suggest structural differences between violent offenders with high psychopathy traits and ASD individuals in the frontotemporal social brain network areas, previously associated with empathy. We also provide evidence of similar abnormal structures in the motor cortex for both of these disorders, possibly related to uniting issues of social cognition.http://www.sciencedirect.com/science/article/pii/S2213158222001814Social brain networksSocial cognitionVoxel-based morphometryPre-motor cortexFrontotemporal cortexEmpathy |
| spellingShingle | Tuomo Noppari Lihua Sun Lasse Lukkarinen Vesa Putkinen Pekka Tani Nina Lindberg Emma Saure Hannu Lauerma Jari Tiihonen Niina Venetjoki Marja Salomaa Päivi Rautio Jussi Hirvonen Juha Salmi Lauri Nummenmaa Brain structural alterations in autism and criminal psychopathy NeuroImage: Clinical Social brain networks Social cognition Voxel-based morphometry Pre-motor cortex Frontotemporal cortex Empathy |
| title | Brain structural alterations in autism and criminal psychopathy |
| title_full | Brain structural alterations in autism and criminal psychopathy |
| title_fullStr | Brain structural alterations in autism and criminal psychopathy |
| title_full_unstemmed | Brain structural alterations in autism and criminal psychopathy |
| title_short | Brain structural alterations in autism and criminal psychopathy |
| title_sort | brain structural alterations in autism and criminal psychopathy |
| topic | Social brain networks Social cognition Voxel-based morphometry Pre-motor cortex Frontotemporal cortex Empathy |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222001814 |
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