In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls

In Vitro Analysis of Biological Activity of Circulating Cell-Free DNA Isolated from Blood Plasma of Schizophrenic Patients and Healthy Controls

Schizophrenia is associated with low-grade systemic inflammation. Circulating cell-free DNA (c-cfDNA) belongs to the DAMP class. The major research question was: can the c-cfDNA of schizophrenic patients (sz-cfDNA) stimulate the DNA sensor genes, which control the innate immunity? We investigated th...

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Bibliographic Details
Main Authors: Elizaveta S. Ershova, Galina V. Shmarina, Lev N. Porokhovnik, Natalia V. Zakharova, George P. Kostyuk, Pavel E. Umriukhin, Sergey I. Kutsev, Vasilina A. Sergeeva, Natalia N. Veiko, Svetlana V. Kostyuk
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Genes
Subjects:
schizophrenia
cell-free DNA
TLR9
AIM2
STING
RIG-I
Online Access:https://www.mdpi.com/2073-4425/13/3/551

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