Biomechanical homeostasis in ocular diseases: A mini-review
Diabetes mellitus-induced hyperglycemia is responsible for multiple pathological ocular alternations from vasculopathy to biomechanical dyshomeostasis. Biomechanical homeostasis is crucial to maintain the normal physiological condition of the eyes. Biomechanical features vary in eye tissues regardin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1106728/full |
| _version_ | 1797951423368921088 |
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| author | Ying Cheng Tianmin Ren Ningli Wang Ningli Wang Ningli Wang |
| author_facet | Ying Cheng Tianmin Ren Ningli Wang Ningli Wang Ningli Wang |
| author_sort | Ying Cheng |
| collection | DOAJ |
| description | Diabetes mellitus-induced hyperglycemia is responsible for multiple pathological ocular alternations from vasculopathy to biomechanical dyshomeostasis. Biomechanical homeostasis is crucial to maintain the normal physiological condition of the eyes. Biomechanical features vary in eye tissues regarding different anatomical positions, tissue components, and cellular functions. The disturbance in biomechanical homeostasis may result in different ocular diseases. In this review, we provide a preliminary sketch of the latest evidence on the mechano-environment of the eyeball and its possible influencing factors, thereby underscoring the relationship between the dyshomeostasis of ocular biomechanics and common eye diseases (e.g., diabetic retinopathy, keratoconus, glaucoma, spaceflight-associated neuro-ocular syndrome, retinal vein occlusion and myopia, etc.). Together with the reported evidence, we further discuss and postulate the potential role of biomechanical homeostasis in ophthalmic pathology. Some latest strategies to investigate the biomechanical properties in ocular diseases help unveil the pathological changes at multiple scales, offering references for making new diagnostic and treatment strategies targeting mechanobiology. |
| first_indexed | 2024-04-10T22:30:22Z |
| format | Article |
| id | doaj.art-0db02e39de734e0eb28a56dbd0784213 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-10T22:30:22Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-0db02e39de734e0eb28a56dbd07842132023-01-17T04:48:15ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-01-011110.3389/fpubh.2023.11067281106728Biomechanical homeostasis in ocular diseases: A mini-reviewYing Cheng0Tianmin Ren1Ningli Wang2Ningli Wang3Ningli Wang4Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaBeijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaBeijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaCollaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, ChinaDiabetes mellitus-induced hyperglycemia is responsible for multiple pathological ocular alternations from vasculopathy to biomechanical dyshomeostasis. Biomechanical homeostasis is crucial to maintain the normal physiological condition of the eyes. Biomechanical features vary in eye tissues regarding different anatomical positions, tissue components, and cellular functions. The disturbance in biomechanical homeostasis may result in different ocular diseases. In this review, we provide a preliminary sketch of the latest evidence on the mechano-environment of the eyeball and its possible influencing factors, thereby underscoring the relationship between the dyshomeostasis of ocular biomechanics and common eye diseases (e.g., diabetic retinopathy, keratoconus, glaucoma, spaceflight-associated neuro-ocular syndrome, retinal vein occlusion and myopia, etc.). Together with the reported evidence, we further discuss and postulate the potential role of biomechanical homeostasis in ophthalmic pathology. Some latest strategies to investigate the biomechanical properties in ocular diseases help unveil the pathological changes at multiple scales, offering references for making new diagnostic and treatment strategies targeting mechanobiology.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1106728/fullbiomechanical homeostasiskeratoconusglaucomadiabetic retinopathymyopia |
| spellingShingle | Ying Cheng Tianmin Ren Ningli Wang Ningli Wang Ningli Wang Biomechanical homeostasis in ocular diseases: A mini-review Frontiers in Public Health biomechanical homeostasis keratoconus glaucoma diabetic retinopathy myopia |
| title | Biomechanical homeostasis in ocular diseases: A mini-review |
| title_full | Biomechanical homeostasis in ocular diseases: A mini-review |
| title_fullStr | Biomechanical homeostasis in ocular diseases: A mini-review |
| title_full_unstemmed | Biomechanical homeostasis in ocular diseases: A mini-review |
| title_short | Biomechanical homeostasis in ocular diseases: A mini-review |
| title_sort | biomechanical homeostasis in ocular diseases a mini review |
| topic | biomechanical homeostasis keratoconus glaucoma diabetic retinopathy myopia |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1106728/full |
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