Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study
AbstractBackground Red blood cell distribution width (RDW) has been assessed during COVID-19 patient hospitalization, however, further research should be done to evaluate RDW from routine community blood tests, before infection, as a risk factor for COVID-19 related hospitalization and mortality.Pat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1968484 |
| _version_ | 1797385674706386944 |
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| author | Tamar Banon Joshua Wortsman Shay Ben Moshe Sivan Gazit Asaf Peretz Amir Ben Tov Gabriel Chodick Galit Perez Tal Patalon |
| author_facet | Tamar Banon Joshua Wortsman Shay Ben Moshe Sivan Gazit Asaf Peretz Amir Ben Tov Gabriel Chodick Galit Perez Tal Patalon |
| author_sort | Tamar Banon |
| collection | DOAJ |
| description | AbstractBackground Red blood cell distribution width (RDW) has been assessed during COVID-19 patient hospitalization, however, further research should be done to evaluate RDW from routine community blood tests, before infection, as a risk factor for COVID-19 related hospitalization and mortality.Patients and methods RDW was measured as a predictor along with age, sex, chronic illnesses, and BMI in logistic regressions to predict hospitalization and mortality. Hospitalization and mortality odds ratios (ORs) were estimated with 95% confidence intervals (CI). RDW was evaluated separately as continuous and discrete (High RDW ≥ 14.5) variables.Results Four thousand one hundred and sixty-eight patients were included in this study, where 824 patients (19.8%) had a high RDW value ≥14.5% (High RDW: 64.7% were female, mean age 58 years [±22] vs. Normal RDW: 60.2% female, mean age 46 years [±19]). Eight hundred and twenty-nine patients had a hospitalization, where the median time between positive PCR and hospital entry was 5 [IQR 1–18] days. Models were analyzed with RDW (continuous) and adjusted for age, sex, comorbidities, and BMI suggested an OR of 1.242 [95% CI = 1.187–2.688] for hospitalization and an OR of 2.911 [95% CI = 1.928–4.395] for mortality (p < .001). RDW (discrete) with the same adjustments presented an OR of 2.232 [95% CI = 1.853–1.300] for hospitalization and an OR of 1.263 [95% CI = 1.166–1.368] for mortality (p < .001).Conclusions High RDW values obtained from community blood tests are associated with greater odds of hospitalization and mortality for patients with COVID-19.KEY MESSAGESRDW measures before SARS-CoV-2 infection is a predictive factor for hospitalization and mortality.RDW threshold of 14.5% provides high sensitivity and specificity for COVID-19 related mortality, comparatively to other blood tests.Patient records should be accessed by clinicians for prior RDW results, if available, followed by further monitoring. |
| first_indexed | 2024-03-08T21:57:42Z |
| format | Article |
| id | doaj.art-0db05ae83cda4c3198c5967ac8b72ba8 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:57:42Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-0db05ae83cda4c3198c5967ac8b72ba82023-12-19T16:46:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015311410141810.1080/07853890.2021.1968484Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort studyTamar Banon0Joshua Wortsman1Shay Ben Moshe2Sivan Gazit3Asaf Peretz4Amir Ben Tov5Gabriel Chodick6Galit Perez7Tal Patalon8Maccabitech Institute for Research & Innovation, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelHead Internal Medicine COVID-19 Ward, Samson Assuta Ashdod University Hospital, Ashdod, IsraelMaccabitech Institute for Research & Innovation, Maccabi Healthcare Services, Tel Aviv, IsraelMaccabitech Institute for Research & Innovation, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelKahn Sagol Maccabi Research & Innovation Center, Maccabi Healthcare Services, Tel Aviv, IsraelAbstractBackground Red blood cell distribution width (RDW) has been assessed during COVID-19 patient hospitalization, however, further research should be done to evaluate RDW from routine community blood tests, before infection, as a risk factor for COVID-19 related hospitalization and mortality.Patients and methods RDW was measured as a predictor along with age, sex, chronic illnesses, and BMI in logistic regressions to predict hospitalization and mortality. Hospitalization and mortality odds ratios (ORs) were estimated with 95% confidence intervals (CI). RDW was evaluated separately as continuous and discrete (High RDW ≥ 14.5) variables.Results Four thousand one hundred and sixty-eight patients were included in this study, where 824 patients (19.8%) had a high RDW value ≥14.5% (High RDW: 64.7% were female, mean age 58 years [±22] vs. Normal RDW: 60.2% female, mean age 46 years [±19]). Eight hundred and twenty-nine patients had a hospitalization, where the median time between positive PCR and hospital entry was 5 [IQR 1–18] days. Models were analyzed with RDW (continuous) and adjusted for age, sex, comorbidities, and BMI suggested an OR of 1.242 [95% CI = 1.187–2.688] for hospitalization and an OR of 2.911 [95% CI = 1.928–4.395] for mortality (p < .001). RDW (discrete) with the same adjustments presented an OR of 2.232 [95% CI = 1.853–1.300] for hospitalization and an OR of 1.263 [95% CI = 1.166–1.368] for mortality (p < .001).Conclusions High RDW values obtained from community blood tests are associated with greater odds of hospitalization and mortality for patients with COVID-19.KEY MESSAGESRDW measures before SARS-CoV-2 infection is a predictive factor for hospitalization and mortality.RDW threshold of 14.5% provides high sensitivity and specificity for COVID-19 related mortality, comparatively to other blood tests.Patient records should be accessed by clinicians for prior RDW results, if available, followed by further monitoring.https://www.tandfonline.com/doi/10.1080/07853890.2021.1968484COVID-19SARS-CoV-2RDW |
| spellingShingle | Tamar Banon Joshua Wortsman Shay Ben Moshe Sivan Gazit Asaf Peretz Amir Ben Tov Gabriel Chodick Galit Perez Tal Patalon Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study Annals of Medicine COVID-19 SARS-CoV-2 RDW |
| title | Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study |
| title_full | Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study |
| title_fullStr | Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study |
| title_full_unstemmed | Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study |
| title_short | Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study |
| title_sort | evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with sars cov 2 a cohort study |
| topic | COVID-19 SARS-CoV-2 RDW |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1968484 |
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