Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation
Steroid hormones e.g., estrogen, progesterone, testosterone and dehydroepiandosterone, act as inter-kingdom quorum chemical signaling compounds. All steroids examined exhibit a steroid concentration specific bi-functionality. At one end of the spectrum, the steroids enhance expression of virulence-a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2018-03-01
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| Series: | AIMS Molecular Science |
| Subjects: | |
| Online Access: | http://www.aimspress.com/Molecular/article/1912/fulltext.html |
| _version_ | 1818491622804946944 |
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| author | Michael W Patt Lisa Conte Mary Blaha Balbina J Plotkin |
| author_facet | Michael W Patt Lisa Conte Mary Blaha Balbina J Plotkin |
| author_sort | Michael W Patt |
| collection | DOAJ |
| description | Steroid hormones e.g., estrogen, progesterone, testosterone and dehydroepiandosterone, act as inter-kingdom quorum chemical signaling compounds. All steroids examined exhibit a steroid concentration specific bi-functionality. At one end of the spectrum, the steroids enhance expression of virulence-associated behaviors, most specifically, increased rate of replication and adherence to surfaces. In contrast, the hormones also function as innate immune system compounds providing first-line protection against essential pathogen behaviors e.g., biofilm formation, which plays a role in initiation of the vast majority of infectious processes, especially chronic infections. Mechanistically, this protection is mediated by both direct effects of steroids on microbes, as well as indirect actions which result in expression of nitric oxide at levels reported to inhibit proper biofilm formation and cause return of sessile cells to a planktonic state. |
| first_indexed | 2024-12-10T17:33:23Z |
| format | Article |
| id | doaj.art-0db08f6ec24848738a52d97279eb1795 |
| institution | Directory Open Access Journal |
| issn | 2372-0301 |
| language | English |
| last_indexed | 2024-12-10T17:33:23Z |
| publishDate | 2018-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj.art-0db08f6ec24848738a52d97279eb17952022-12-22T01:39:37ZengAIMS PressAIMS Molecular Science2372-03012018-03-015111713010.3934/molsci.2018.1.117molsci-05-01-117Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulationMichael W Patt0Lisa Conte1Mary Blaha2Balbina J Plotkin3Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515, USADepartment of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515, USADepartment of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515, USADepartment of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60515, USASteroid hormones e.g., estrogen, progesterone, testosterone and dehydroepiandosterone, act as inter-kingdom quorum chemical signaling compounds. All steroids examined exhibit a steroid concentration specific bi-functionality. At one end of the spectrum, the steroids enhance expression of virulence-associated behaviors, most specifically, increased rate of replication and adherence to surfaces. In contrast, the hormones also function as innate immune system compounds providing first-line protection against essential pathogen behaviors e.g., biofilm formation, which plays a role in initiation of the vast majority of infectious processes, especially chronic infections. Mechanistically, this protection is mediated by both direct effects of steroids on microbes, as well as indirect actions which result in expression of nitric oxide at levels reported to inhibit proper biofilm formation and cause return of sessile cells to a planktonic state.http://www.aimspress.com/Molecular/article/1912/fulltext.htmlbiofilm formationbiofilm dispersalsteroid hormonesestrogensandrogensprogesteronedehydroepiandosteronenitric oxide |
| spellingShingle | Michael W Patt Lisa Conte Mary Blaha Balbina J Plotkin Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation AIMS Molecular Science biofilm formation biofilm dispersal steroid hormones estrogens androgens progesterone dehydroepiandosterone nitric oxide |
| title | Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation |
| title_full | Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation |
| title_fullStr | Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation |
| title_full_unstemmed | Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation |
| title_short | Steroid hormones as interkingdom signaling molecules: Innate immune function and microbial colonization modulation |
| title_sort | steroid hormones as interkingdom signaling molecules innate immune function and microbial colonization modulation |
| topic | biofilm formation biofilm dispersal steroid hormones estrogens androgens progesterone dehydroepiandosterone nitric oxide |
| url | http://www.aimspress.com/Molecular/article/1912/fulltext.html |
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