Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Abstract Background Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities. The etiology of ASD involves both inherited and environmental risk factors, with epigenetic pro...

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Main Authors: Eilis Hannon, Diana Schendel, Christine Ladd-Acosta, Jakob Grove, iPSYCH-Broad ASD Group, Christine Søholm Hansen, Shan V. Andrews, David Michael Hougaard, Michaeline Bresnahan, Ole Mors, Mads Vilhelm Hollegaard, Marie Bækvad-Hansen, Mady Hornig, Preben Bo Mortensen, Anders D. Børglum, Thomas Werge, Marianne Giørtz Pedersen, Merete Nordentoft, Joseph Buxbaum, M. Daniele Fallin, Jonas Bybjerg-Grauholm, Abraham Reichenberg, Jonathan Mill
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Genome Medicine
Subjects:
Autism
DNA methylation
Genetics
Neonatal
Genome-wide association study (GWAS)
Epigenome-wide association study (EWAS)
Online Access:http://link.springer.com/article/10.1186/s13073-018-0527-4

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