Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by the formation of Lewy bodies comprised mainly of α-synuclein. Assessment of skin synuclein has the potential as an excellent diagnostic method with high sensitivity, specificity, and reproducibility...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396422002572 |
| _version_ | 1818468489064611840 |
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| author | Yihang Han Di Wu Yanjuan Wang Jian Xie Zhijun Zhang |
| author_facet | Yihang Han Di Wu Yanjuan Wang Jian Xie Zhijun Zhang |
| author_sort | Yihang Han |
| collection | DOAJ |
| description | Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by the formation of Lewy bodies comprised mainly of α-synuclein. Assessment of skin synuclein has the potential as an excellent diagnostic method with high sensitivity, specificity, and reproducibility that is also convenient and acceptable to patients. In this review, we summarize findings regarding the characteristics of cutaneous nerve p-α-syn or α-syn deposits and their correlations with clinical phenotypes in PD patients with and without orthostatic hypotension and LRRK2, GBA, and SNCA gene mutations. This review can serve as a reference for the diagnosis and classification of PD based on α-syn deposit patterns and to deeply explore its pathogenesis. Funding statement: The work was partly supported by the National Natural Science Key Foundation of China (No. 81830040 and No 82130042) and the Program of Excellent Talents in Medical Science of Jiangsu Province (No. JCRCA2016006) . |
| first_indexed | 2024-04-13T21:12:53Z |
| format | Article |
| id | doaj.art-0db7d6b0d485438e963d421dff3b6f80 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-04-13T21:12:53Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-0db7d6b0d485438e963d421dff3b6f802022-12-22T02:29:47ZengElsevierEBioMedicine2352-39642022-06-0180104076Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypesYihang Han0Di Wu1Yanjuan Wang2Jian Xie3Zhijun Zhang4Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, ChinaDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, ChinaDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, ChinaDepartment of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, ChinaCorresponding author.; Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, 87 Dingjia Qiao, Nanjing, Jiangsu 210009, ChinaSummary: Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by the formation of Lewy bodies comprised mainly of α-synuclein. Assessment of skin synuclein has the potential as an excellent diagnostic method with high sensitivity, specificity, and reproducibility that is also convenient and acceptable to patients. In this review, we summarize findings regarding the characteristics of cutaneous nerve p-α-syn or α-syn deposits and their correlations with clinical phenotypes in PD patients with and without orthostatic hypotension and LRRK2, GBA, and SNCA gene mutations. This review can serve as a reference for the diagnosis and classification of PD based on α-syn deposit patterns and to deeply explore its pathogenesis. Funding statement: The work was partly supported by the National Natural Science Key Foundation of China (No. 81830040 and No 82130042) and the Program of Excellent Talents in Medical Science of Jiangsu Province (No. JCRCA2016006) .http://www.sciencedirect.com/science/article/pii/S2352396422002572Parkinson's diseaseAlpha-synucleinAutonomic dysfunctionLRRK2GBASNCA |
| spellingShingle | Yihang Han Di Wu Yanjuan Wang Jian Xie Zhijun Zhang Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes EBioMedicine Parkinson's disease Alpha-synuclein Autonomic dysfunction LRRK2 GBA SNCA |
| title | Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes |
| title_full | Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes |
| title_fullStr | Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes |
| title_full_unstemmed | Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes |
| title_short | Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes |
| title_sort | skin alpha synuclein deposit patterns a predictor of parkinson s disease subtypes |
| topic | Parkinson's disease Alpha-synuclein Autonomic dysfunction LRRK2 GBA SNCA |
| url | http://www.sciencedirect.com/science/article/pii/S2352396422002572 |
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