Identification and targeting of a HES1‐YAP1‐CDKN1C functional interaction in fusion‐negative rhabdomyosarcoma

Identification and targeting of a HES1‐YAP1‐CDKN1C functional interaction in fusion‐negative rhabdomyosarcoma

Rhabdomyosarcoma (RMS), a cancer characterized by features of skeletal muscle, is the most common soft‐tissue sarcoma of childhood. With 5‐year survival rates among high‐risk groups at < 30%, new therapeutics are desperately needed. Previously, using a myoblast‐based model of fusion‐negative RMS...

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Bibliographic Details
Main Authors: Alexander R. Kovach, Kristianne M. Oristian, David G. Kirsch, Rex C. Bentley, Changde Cheng, Xiang Chen, Po‐Han Chen, Jen‐Tsan Ashley Chi, Corinne M. Linardic
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Molecular Oncology
Subjects:
CDKN1C
HES1
rhabdomyosarcoma
YAP1
Online Access:https://doi.org/10.1002/1878-0261.13304

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