THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS
The results from the selective validation research into the association between genetic polymorphisms and the frequency of cytogenetic abnormalities on a large independent sample are analyzed. These polymorphisms have been identified previously during own microarray studies. It has been shown an ass...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2014-06-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/67 |
| _version_ | 1797872944717758464 |
|---|---|
| author | M. V. Khalyuzova N. V. Litvyakov A. E. Sazonov Ye. N. Albakh D. S. Isubakova A. B. Karpov R. M. Takhauov |
| author_facet | M. V. Khalyuzova N. V. Litvyakov A. E. Sazonov Ye. N. Albakh D. S. Isubakova A. B. Karpov R. M. Takhauov |
| author_sort | M. V. Khalyuzova |
| collection | DOAJ |
| description | The results from the selective validation research into the association between genetic polymorphisms and the frequency of cytogenetic abnormalities on a large independent sample are analyzed. These polymorphisms have been identified previously during own microarray studies. It has been shown an association with the frequency of dicentric and ring chromosomes induced by radiation exposure. The study was conducted among Siberian Group of Chemical Enterprises healthy employees (n = 573) exposed to professional irradiation in a dose range of 40–400 mSv. We have found that 5 SNP are confirmed to be associated with the frequency of dicentric and ring: INSR rs1051690 – insulin receptor gene; WRNrs2725349 – Werner syndrome gene, RecQ helicase-like; VCAM1 rs1041163 – vascular cell adhesion molecule 1 gene; PCTP rs2114443 – phosphatidylcholine transfer protein gene; TNKS rs7462102 – tankyrase gene; TRF1-interacting ankyrin-related ADP-ribose polymerase. IGF1 rs2373721 – insulin-like growth factor 1 gene has not confirmed to be associated with the frequency of dicentric and ring chromosomes. |
| first_indexed | 2024-04-10T01:07:06Z |
| format | Article |
| id | doaj.art-0db86c6b63f34d969baf3a700b6c81f4 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:06Z |
| publishDate | 2014-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-0db86c6b63f34d969baf3a700b6c81f42023-03-13T09:58:20ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-06-01133707910.20538/1682-0363-2014-3-70-7965THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERSM. V. Khalyuzova0N. V. Litvyakov1A. E. Sazonov2Ye. N. Albakh3D. S. Isubakova4A. B. Karpov5R. M. Takhauov6Северский биофизический научный центр ФМБА России, Северск; Национальный исследовательский Томский государственный университет, ТомскСеверский биофизический научный центр ФМБА России, Северск, Научно-исследовательский институт онкологии Сибирского отделения РАМН, Томск, Национальный исследовательский Томский государственный университет, ТомскСеверский биофизический научный центр ФМБА России, Северск, Сибирский государственный медицинский университет, ТомскСеверский биофизический научный центр ФМБА России, СеверскСеверский биофизический научный центр ФМБА России, СеверскКарпов Андрей Борисович, доктор медицинских наук, профессор, зам. директора Северского биофизического научного центра ФМБА России; профессор кафедры организации здравоохранения и общественного здоровья СибГМУСеверский биофизический научный центр ФМБА России, Северск; Сибирский государственный медицинский университет, ТомскThe results from the selective validation research into the association between genetic polymorphisms and the frequency of cytogenetic abnormalities on a large independent sample are analyzed. These polymorphisms have been identified previously during own microarray studies. It has been shown an association with the frequency of dicentric and ring chromosomes induced by radiation exposure. The study was conducted among Siberian Group of Chemical Enterprises healthy employees (n = 573) exposed to professional irradiation in a dose range of 40–400 mSv. We have found that 5 SNP are confirmed to be associated with the frequency of dicentric and ring: INSR rs1051690 – insulin receptor gene; WRNrs2725349 – Werner syndrome gene, RecQ helicase-like; VCAM1 rs1041163 – vascular cell adhesion molecule 1 gene; PCTP rs2114443 – phosphatidylcholine transfer protein gene; TNKS rs7462102 – tankyrase gene; TRF1-interacting ankyrin-related ADP-ribose polymerase. IGF1 rs2373721 – insulin-like growth factor 1 gene has not confirmed to be associated with the frequency of dicentric and ring chromosomes.https://bulletin.ssmu.ru/jour/article/view/67полиморфизм геновхромосомные аберрациииндивидуальная радиочувствительностьрадиационное воздействие |
| spellingShingle | M. V. Khalyuzova N. V. Litvyakov A. E. Sazonov Ye. N. Albakh D. S. Isubakova A. B. Karpov R. M. Takhauov THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS Бюллетень сибирской медицины полиморфизм генов хромосомные аберрации индивидуальная радиочувствительность радиационное воздействие |
| title | THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS |
| title_full | THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS |
| title_fullStr | THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS |
| title_full_unstemmed | THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS |
| title_short | THE VALIDATION OF THE RESULTS OF MICROARRAY STUDIES OF ASSOCIATION BETWEEN GENE POLYMORPHISMS AND THE FREQUENCY OF RADIATION EXPOSURE MARKERS |
| title_sort | validation of the results of microarray studies of association between gene polymorphisms and the frequency of radiation exposure markers |
| topic | полиморфизм генов хромосомные аберрации индивидуальная радиочувствительность радиационное воздействие |
| url | https://bulletin.ssmu.ru/jour/article/view/67 |
| work_keys_str_mv | AT mvkhalyuzova thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT nvlitvyakov thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT aesazonov thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT yenalbakh thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT dsisubakova thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT abkarpov thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT rmtakhauov thevalidationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT mvkhalyuzova validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT nvlitvyakov validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT aesazonov validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT yenalbakh validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT dsisubakova validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT abkarpov validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers AT rmtakhauov validationoftheresultsofmicroarraystudiesofassociationbetweengenepolymorphismsandthefrequencyofradiationexposuremarkers |