<i>N</i>-Terminally Lipidated Sialorphin Analogs—Synthesis, Molecular Modeling, In Vitro Effect on Enkephalins Degradation by NEP and Treatment of Intestinal Inflammation in Mice

<i>N</i>-Terminally Lipidated Sialorphin Analogs—Synthesis, Molecular Modeling, In Vitro Effect on Enkephalins Degradation by NEP and Treatment of Intestinal Inflammation in Mice

Pharmacotherapy for inflammatory bowel disease (IBD) is difficult, and some patients do not respond to currently available treatments. Therefore, the discovery of novel anti-IBD agents is imperative. Our aim was the synthesis of lipidated analogs of sialorphin and the in vitro characterization of th...

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Bibliographic Details
Main Authors: Małgorzata Sobocińska, Jakub Fichna, Artur Giełdoń, Piotr Skowron, Elżbieta Kamysz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
enkephalins
sialorphin
neutral endopeptidase
peptides synthesis
molecular modelling
structure–activity relationship
Online Access:https://www.mdpi.com/1422-0067/23/22/14450

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