Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai
In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (1–4), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compou...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-12-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/10/12/2817 |
| _version_ | 1828372326119374848 |
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| author | Bin-Gui Wang Chun-Shun Li Hong Sun Xiao-Ming Li Chuan-Ming Cui Yi Liang |
| author_facet | Bin-Gui Wang Chun-Shun Li Hong Sun Xiao-Ming Li Chuan-Ming Cui Yi Liang |
| author_sort | Bin-Gui Wang |
| collection | DOAJ |
| description | In addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (1–4), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM. |
| first_indexed | 2024-04-14T07:02:10Z |
| format | Article |
| id | doaj.art-0db8d42e30c24938903565b2739de247 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T07:02:10Z |
| publishDate | 2012-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-0db8d42e30c24938903565b2739de2472022-12-22T02:06:44ZengMDPI AGMarine Drugs1660-33972012-12-0110122817282510.3390/md10122817Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamuraiBin-Gui WangChun-Shun LiHong SunXiao-Ming LiChuan-Ming CuiYi LiangIn addition to 13 known compounds, four new bisabolane sesquiterpenes, okamurenes A–D (1–4), a new chamigrane derivative, okamurene E (5), and a new C12-acetogenin, okamuragenin (6), were isolated from the marine red alga Laurencia okamurai. The structures of these compounds were determined through detailed spectroscopic analyses. Of these, okamurenes A and B (1 and 2) are the first examples of bromobisabolane sesquiterpenes possessing a phenyl moiety among Laurencia-derived sesquiterpenes, while okamuragenin (6) was the first acetogenin aldehyde possessing a C12-carbon skeleton. Each of the isolated compounds was evaluated for the brine shrimp (Artemia salina) lethal assay and 7-hydroxylaurene displayed potent lethality with LD50 1.8 μM.http://www.mdpi.com/1660-3397/10/12/2817marine algaLaurencia okamuraibisabolane sesquiterpeneC12-acetogeninbrine shrimp lethality |
| spellingShingle | Bin-Gui Wang Chun-Shun Li Hong Sun Xiao-Ming Li Chuan-Ming Cui Yi Liang Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai Marine Drugs marine alga Laurencia okamurai bisabolane sesquiterpene C12-acetogenin brine shrimp lethality |
| title | Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai |
| title_full | Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai |
| title_fullStr | Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai |
| title_full_unstemmed | Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai |
| title_short | Sesquiterpene and Acetogenin Derivatives from the Marine Red Alga Laurencia okamurai |
| title_sort | sesquiterpene and acetogenin derivatives from the marine red alga laurencia okamurai |
| topic | marine alga Laurencia okamurai bisabolane sesquiterpene C12-acetogenin brine shrimp lethality |
| url | http://www.mdpi.com/1660-3397/10/12/2817 |
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