USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

Abstract Abnormal alternative splicing (AS) caused by alterations in spliceosomal factors is implicated in cancers. Standard models posit that splice site selection is mainly determined by early spliceosomal U1 and U2 snRNPs. Whether and how other mid/late-acting spliceosome components such as USP39...

Full description

Bibliographic Details
Main Authors: Jingyi Zheng, Shasha Wu, Mao Tang, Shaoyan Xi, Yanchen Wang, Jun Ren, Hao Luo, Pengchao Hu, Liangzhan Sun, Yuyang Du, Hui Yang, Fenfen Wang, Han Gao, Ziwei Dai, Xijun Ou, Yan Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06210-3

Similar Items

Similar Items