DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC
An accurate and sensitive HPLC method has been developed for the determination of mebhydroline napadisylate in the tablet. The Chromatography was performed on a reversed phase C-18 column, using a mobile phase of acetonitrile : ammonia 25% (80 : 20 v/v) at ambient temperature 25±5 °C and UV detectio...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2010-06-01
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| Series: | Indonesian Journal of Chemistry |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/21610 |
| _version_ | 1819117703321878528 |
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| author | Lestyo Wulandari |
| author_facet | Lestyo Wulandari |
| author_sort | Lestyo Wulandari |
| collection | DOAJ |
| description | An accurate and sensitive HPLC method has been developed for the determination of mebhydroline napadisylate in the tablet. The Chromatography was performed on a reversed phase C-18 column, using a mobile phase of acetonitrile : ammonia 25% (80 : 20 v/v) at ambient temperature 25±5 °C and UV detection operates at 320 nm in an overall analysis time of about 15 min, based on peak area. This HPLC method is selective, precise, and accurate and can be used for routine analysis of pharmaceutical preparation in industrial quality-control laboratories.
Keywords : HPLC, mebhydroline napadisylate, validation |
| first_indexed | 2024-12-22T05:37:12Z |
| format | Article |
| id | doaj.art-0db9ad0d247d4a1f8a4d34f4bf7b02be |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-12-22T05:37:12Z |
| publishDate | 2010-06-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-0db9ad0d247d4a1f8a4d34f4bf7b02be2022-12-21T18:37:17ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782010-06-018337737910.22146/ijc.2161014708DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLCLestyo Wulandari0Department of Chemical Pharmacy, School of Pharmacy, Jember University, Jl. Kalimantan I/2, Jember, 68121An accurate and sensitive HPLC method has been developed for the determination of mebhydroline napadisylate in the tablet. The Chromatography was performed on a reversed phase C-18 column, using a mobile phase of acetonitrile : ammonia 25% (80 : 20 v/v) at ambient temperature 25±5 °C and UV detection operates at 320 nm in an overall analysis time of about 15 min, based on peak area. This HPLC method is selective, precise, and accurate and can be used for routine analysis of pharmaceutical preparation in industrial quality-control laboratories. Keywords : HPLC, mebhydroline napadisylate, validationhttps://jurnal.ugm.ac.id/ijc/article/view/21610 |
| spellingShingle | Lestyo Wulandari DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC Indonesian Journal of Chemistry |
| title | DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC |
| title_full | DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC |
| title_fullStr | DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC |
| title_full_unstemmed | DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC |
| title_short | DETERMINATION AND VALIDATION OF MEBHYDROLINE NAPADISYLATE IN TABLETS BY HPLC |
| title_sort | determination and validation of mebhydroline napadisylate in tablets by hplc |
| url | https://jurnal.ugm.ac.id/ijc/article/view/21610 |
| work_keys_str_mv | AT lestyowulandari determinationandvalidationofmebhydrolinenapadisylateintabletsbyhplc |