From Batch to the Semi-Continuous Flow Hydrogenation of <i>p</i>NB, <i>p</i>NZ-Protected Meropenem

From Batch to the Semi-Continuous Flow Hydrogenation of <i>p</i>NB, <i>p</i>NZ-Protected Meropenem

Meropenem is currently the most common carbapenem in clinical applications. Industrially, the final synthetic step is characterized by a heterogeneous catalytic hydrogenation in batch mode with hydrogen and Pd/C. The required high-quality standard is very difficult to meet and specific conditions ar...

書誌詳細
主要な著者:	Marziale Comito, Riccardo Monguzzi, Silvia Tagliapietra, Angelo Maspero, Giovanni Palmisano, Giancarlo Cravotto
フォーマット:	論文
言語:	English
出版事項:	MDPI AG 2023-04-01
シリーズ:	Pharmaceutics
主題:	flow chemistry microwave-assisted semi-continuous synthesis meropenem hydrogenation drug synthesis
オンライン･アクセス:	https://www.mdpi.com/1999-4923/15/5/1322

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