In-silico studies to recognize repurposing therapeutics toward arginase-I inhibitors as a potential onco-immunomodulators

In-silico studies to recognize repurposing therapeutics toward arginase-I inhibitors as a potential onco-immunomodulators

Rudolf Virchow was the first person to point out the important link between immune function and cancer. He did this by noticing that leukocytes were often found in tumors. Overexpression of arginase 1 (ARG1) and inducible nitric oxide synthase (iNOS) in myeloid-derived suppressor cells (MDSCs) and t...

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Bibliographic Details
Main Authors: Magdi E. A. Zaki, Sami A. Al-Hussain, Aamal A. Al-Mutairi, Abdul Samad, Arabinda Ghosh, Somdatta Chaudhari, Pravin N. Khatale, Prashant Ajmire, Rahul D. Jawarkar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
immunomodulatory
arginase-i
QSAR
virtual screening
MD simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1129997/full

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