Radiation-induced erectile dysfunction: Recent advances and future directions
Prostate cancer is one of the most prevalent cancers and the second leading cause of cancer-related deaths in men in the United States. A large number of patients undergo radiation therapy (RT) as a standard care of treatment; however, RT causes erectile dysfunction (radiation-induced erectile dysfu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-07-01
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| Series: | Advances in Radiation Oncology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452109416300112 |
| _version_ | 1819261094832635904 |
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| author | Javed Mahmood, PhD Aksinija A. Shamah, MSc T. Michael Creed, MSc Radmila Pavlovic, BSc Hotaka Matsui, MD, PhD Masaki Kimura, MD, PhD Jason Molitoris, MD, PhD Hem Shukla, PhD Isabel Jackson, PhD Zeljko Vujaskovic, MD, PhD |
| author_facet | Javed Mahmood, PhD Aksinija A. Shamah, MSc T. Michael Creed, MSc Radmila Pavlovic, BSc Hotaka Matsui, MD, PhD Masaki Kimura, MD, PhD Jason Molitoris, MD, PhD Hem Shukla, PhD Isabel Jackson, PhD Zeljko Vujaskovic, MD, PhD |
| author_sort | Javed Mahmood, PhD |
| collection | DOAJ |
| description | Prostate cancer is one of the most prevalent cancers and the second leading cause of cancer-related deaths in men in the United States. A large number of patients undergo radiation therapy (RT) as a standard care of treatment; however, RT causes erectile dysfunction (radiation-induced erectile dysfunction; RiED) because of late side effects after RT that significantly affects quality of life of prostate cancer patients. Within 5 years of RT, approximately 50% of patients could develop RiED. Based on the past and current research findings and number of publications from our group, the precise mechanism of RiED is under exploration in detail. Recent investigations have shown prostate RT induces significant morphologic arterial damage with aberrant alterations in internal pudendal arterial tone. Prostatic RT also reduces motor function in the cavernous nerve which may attribute to axonal degeneration may contributing to RiED. Furthermore, the advances in radiogenomics such as radiation induced somatic mutation identification, copy number variation and genome-wide association studies has significantly facilitated identification of biomarkers that could be used to monitoring radiation-induced late toxicity and damage to the nerves; thus, genomic- and proteomic-based biomarkers could greatly improve treatment and minimize arterial tissue and nerve damage. Further, advanced technologies such as proton beam therapy that precisely target tumor and significantly reduce off-target damage to vital organs and healthy tissues. In this review, we summarize recent advances in RiED research and novel treatment modalities for RiED. We also discuss the possible molecular mechanism involved in the development of RiED in prostate cancer patients. Further, we discuss various readily available methods as well as novel strategies such as stem cell therapies, shockwave therapy, nerve grafting with tissue engineering, and nutritional supplementations might be used to mitigate or cure sexual dysfunction following radiation treatment. |
| first_indexed | 2024-12-23T19:36:20Z |
| format | Article |
| id | doaj.art-0dbda6f2192f44b0a0bdbb6ddc7402c5 |
| institution | Directory Open Access Journal |
| issn | 2452-1094 |
| language | English |
| last_indexed | 2024-12-23T19:36:20Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Radiation Oncology |
| spelling | doaj.art-0dbda6f2192f44b0a0bdbb6ddc7402c52022-12-21T17:33:47ZengElsevierAdvances in Radiation Oncology2452-10942016-07-011316116910.1016/j.adro.2016.05.003Radiation-induced erectile dysfunction: Recent advances and future directionsJaved Mahmood, PhD0Aksinija A. Shamah, MSc1T. Michael Creed, MSc2Radmila Pavlovic, BSc3Hotaka Matsui, MD, PhD4Masaki Kimura, MD, PhD5Jason Molitoris, MD, PhD6Hem Shukla, PhD7Isabel Jackson, PhD8Zeljko Vujaskovic, MD, PhD9Division of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandDivision of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandDivision of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandDivision of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandThe James Buchanan Brady Urological Institute, and Department of Urology, Johns Hopkins School of Medicine, Baltimore, MarylandDepartment of Urology, School of Medicine, Teikyo University, Tokyo, JapanDivision of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MarylandDivision of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandDivision of Translational Radiation Sciences, Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MarylandProstate cancer is one of the most prevalent cancers and the second leading cause of cancer-related deaths in men in the United States. A large number of patients undergo radiation therapy (RT) as a standard care of treatment; however, RT causes erectile dysfunction (radiation-induced erectile dysfunction; RiED) because of late side effects after RT that significantly affects quality of life of prostate cancer patients. Within 5 years of RT, approximately 50% of patients could develop RiED. Based on the past and current research findings and number of publications from our group, the precise mechanism of RiED is under exploration in detail. Recent investigations have shown prostate RT induces significant morphologic arterial damage with aberrant alterations in internal pudendal arterial tone. Prostatic RT also reduces motor function in the cavernous nerve which may attribute to axonal degeneration may contributing to RiED. Furthermore, the advances in radiogenomics such as radiation induced somatic mutation identification, copy number variation and genome-wide association studies has significantly facilitated identification of biomarkers that could be used to monitoring radiation-induced late toxicity and damage to the nerves; thus, genomic- and proteomic-based biomarkers could greatly improve treatment and minimize arterial tissue and nerve damage. Further, advanced technologies such as proton beam therapy that precisely target tumor and significantly reduce off-target damage to vital organs and healthy tissues. In this review, we summarize recent advances in RiED research and novel treatment modalities for RiED. We also discuss the possible molecular mechanism involved in the development of RiED in prostate cancer patients. Further, we discuss various readily available methods as well as novel strategies such as stem cell therapies, shockwave therapy, nerve grafting with tissue engineering, and nutritional supplementations might be used to mitigate or cure sexual dysfunction following radiation treatment.http://www.sciencedirect.com/science/article/pii/S2452109416300112 |
| spellingShingle | Javed Mahmood, PhD Aksinija A. Shamah, MSc T. Michael Creed, MSc Radmila Pavlovic, BSc Hotaka Matsui, MD, PhD Masaki Kimura, MD, PhD Jason Molitoris, MD, PhD Hem Shukla, PhD Isabel Jackson, PhD Zeljko Vujaskovic, MD, PhD Radiation-induced erectile dysfunction: Recent advances and future directions Advances in Radiation Oncology |
| title | Radiation-induced erectile dysfunction: Recent advances and future directions |
| title_full | Radiation-induced erectile dysfunction: Recent advances and future directions |
| title_fullStr | Radiation-induced erectile dysfunction: Recent advances and future directions |
| title_full_unstemmed | Radiation-induced erectile dysfunction: Recent advances and future directions |
| title_short | Radiation-induced erectile dysfunction: Recent advances and future directions |
| title_sort | radiation induced erectile dysfunction recent advances and future directions |
| url | http://www.sciencedirect.com/science/article/pii/S2452109416300112 |
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