Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery

Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery

Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibition and an essential function of H3K27me3 in regulati...

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Bibliographic Details
Main Authors: Allison P. Siegenfeld, Shelby A. Roseman, Heejin Roh, Nicholas Z. Lue, Corin C. Wagen, Eric Zhou, Sarah E. Johnstone, Martin J. Aryee, Brian B. Liau
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31857-5

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https://doi.org/10.1038/s41467-022-31857-5

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