Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis
Background: Left ventricular diastolic dysfunction (LVDD) is observed in the early stages of chronic kidney disease (CKD) and may lead to heart failure with preserved ejection fraction (HFpEF). The purpose of our study was to investigate the association between metabolic, nutritional and inflammator...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4664 |
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| author | Katarzyna Romejko Aleksandra Rymarz Katarzyna Szamotulska Zbigniew Bartoszewicz Tomasz Rozmyslowicz Stanisław Niemczyk |
| author_facet | Katarzyna Romejko Aleksandra Rymarz Katarzyna Szamotulska Zbigniew Bartoszewicz Tomasz Rozmyslowicz Stanisław Niemczyk |
| author_sort | Katarzyna Romejko |
| collection | DOAJ |
| description | Background: Left ventricular diastolic dysfunction (LVDD) is observed in the early stages of chronic kidney disease (CKD) and may lead to heart failure with preserved ejection fraction (HFpEF). The purpose of our study was to investigate the association between metabolic, nutritional and inflammatory parameters and LVDD in CKD and non-CKD patients. Methods: Two groups of patients were recruited to the study: 93 men with CKD and eGFR lower than 60 mL/min/1.73 m<sup>2</sup> and 40 men without kidney function decrease with eGFR ≥ 60 mL/min/1.73 m<sup>2</sup>. Transthoracic echocardiography was performed to evaluate the diastolic function of the left ventricle. Bioimpedance spectroscopy (BIS) was used to measure overhydration and lean body mass. We also measured the serum concentrations of albumin, glucose, haemoglobin A1c (HgbA1c), fibrinogen, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and osteoprotegerin (OPG). Results: We observed that elevated serum fibrinogen and glucose concentrations were associated with LVDD independently of CKD status. Serum fibrinogen concentrations increased with the advancement of LVDD. Low albumin concentrations in CKD were related with LVDD. In the control group, lower muscle mass presented as lean tissue index (LTI) and lean tissue mass (LTM), and overhydration were associated with LVDD. In the group of patients without kidney function decrease the OPG concentrations were significantly higher in those with LVDD, and they rose with the advancement of LVDD. Conclusions: Elevated inflammatory parameters, increased serum glucose concentrations and worse nutritional status are the states that may impair the diastolic function of the left ventricle in CKD and non-CKD patients. Serum OPG levels are elevated in patients without kidney function decrease and LVDD and its concentrations rise with the advancement of LVDD. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-09T18:45:41Z |
| publishDate | 2022-11-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0dc0059a1e664070971090ff9c89f4d02023-11-24T06:15:14ZengMDPI AGNutrients2072-66432022-11-011421466410.3390/nu14214664Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with DialysisKatarzyna Romejko0Aleksandra Rymarz1Katarzyna Szamotulska2Zbigniew Bartoszewicz3Tomasz Rozmyslowicz4Stanisław Niemczyk5Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, PolandDepartment of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, PolandDepartment of Epidemiology and Biostatistics, Institute of Mother and Child, Kasprzaka Street, 17a, 01-211 Warsaw, PolandDepartment of Internal Diseases and Endocrinology, Medical University of Warsaw, 1a Banacha Street, 02-097 Warsaw, PolandDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, R.217 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USADepartment of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, PolandBackground: Left ventricular diastolic dysfunction (LVDD) is observed in the early stages of chronic kidney disease (CKD) and may lead to heart failure with preserved ejection fraction (HFpEF). The purpose of our study was to investigate the association between metabolic, nutritional and inflammatory parameters and LVDD in CKD and non-CKD patients. Methods: Two groups of patients were recruited to the study: 93 men with CKD and eGFR lower than 60 mL/min/1.73 m<sup>2</sup> and 40 men without kidney function decrease with eGFR ≥ 60 mL/min/1.73 m<sup>2</sup>. Transthoracic echocardiography was performed to evaluate the diastolic function of the left ventricle. Bioimpedance spectroscopy (BIS) was used to measure overhydration and lean body mass. We also measured the serum concentrations of albumin, glucose, haemoglobin A1c (HgbA1c), fibrinogen, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and osteoprotegerin (OPG). Results: We observed that elevated serum fibrinogen and glucose concentrations were associated with LVDD independently of CKD status. Serum fibrinogen concentrations increased with the advancement of LVDD. Low albumin concentrations in CKD were related with LVDD. In the control group, lower muscle mass presented as lean tissue index (LTI) and lean tissue mass (LTM), and overhydration were associated with LVDD. In the group of patients without kidney function decrease the OPG concentrations were significantly higher in those with LVDD, and they rose with the advancement of LVDD. Conclusions: Elevated inflammatory parameters, increased serum glucose concentrations and worse nutritional status are the states that may impair the diastolic function of the left ventricle in CKD and non-CKD patients. Serum OPG levels are elevated in patients without kidney function decrease and LVDD and its concentrations rise with the advancement of LVDD.https://www.mdpi.com/2072-6643/14/21/4664chronic kidney diseaseleft ventricular diastolic dysfunctionbioimpedance spectroscopymetabolicinflammatory parameters |
| spellingShingle | Katarzyna Romejko Aleksandra Rymarz Katarzyna Szamotulska Zbigniew Bartoszewicz Tomasz Rozmyslowicz Stanisław Niemczyk Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis Nutrients chronic kidney disease left ventricular diastolic dysfunction bioimpedance spectroscopy metabolic inflammatory parameters |
| title | Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis |
| title_full | Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis |
| title_fullStr | Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis |
| title_full_unstemmed | Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis |
| title_short | Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis |
| title_sort | left ventricular diastolic dysfunction in chronic kidney disease patients not treated with dialysis |
| topic | chronic kidney disease left ventricular diastolic dysfunction bioimpedance spectroscopy metabolic inflammatory parameters |
| url | https://www.mdpi.com/2072-6643/14/21/4664 |
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