Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses
Magnetic resonance imaging (MRI) and positron emission tomography (PET) are neuroimaging modalities typically used for evaluating brain changes in Alzheimer’s disease (AD). Due to their complementary nature, their combination can provide more accurate AD diagnosis or prognosis. In this work, we appl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00380/full |
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| author | Vahab Youssofzadeh Vahab Youssofzadeh Bernadette McGuinness Liam P. Maguire KongFatt Wong-Lin |
| author_facet | Vahab Youssofzadeh Vahab Youssofzadeh Bernadette McGuinness Liam P. Maguire KongFatt Wong-Lin |
| author_sort | Vahab Youssofzadeh |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) and positron emission tomography (PET) are neuroimaging modalities typically used for evaluating brain changes in Alzheimer’s disease (AD). Due to their complementary nature, their combination can provide more accurate AD diagnosis or prognosis. In this work, we apply a multi-modal imaging machine-learning framework to enhance AD classification and prediction of diagnosis of subject-matched gray matter MRI and Pittsburgh compound B (PiB)-PET data related to 58 AD, 108 mild cognitive impairment (MCI) and 120 healthy elderly (HE) subjects from the Australian imaging, biomarkers and lifestyle (AIBL) dataset. Specifically, we combined a Dartel algorithm to enhance anatomical registration with multi-kernel learning (MKL) technique, yielding an average of >95% accuracy for three binary classification problems: AD-vs.-HE, MCI-vs.-HE and AD-vs.-MCI, a considerable improvement from individual modality approach. Consistent with t-contrasts, the MKL weight maps revealed known brain regions associated with AD, i.e., (para)hippocampus, posterior cingulate cortex and bilateral temporal gyrus. Importantly, MKL regression analysis provided excellent predictions of diagnosis of individuals by r2 = 0.86. In addition, we found significant correlations between the MKL classification and delayed memory recall scores with r2 = 0.62 (p < 0.01). Interestingly, outliers in the regression model for diagnosis were mainly converter samples with a higher likelihood of converting to the inclined diagnostic category. Overall, our work demonstrates the successful application of MKL with Dartel on combined neuromarkers from different neuroimaging modalities in the AIBL data. This lends further support in favor of machine learning approach in improving the diagnosis and risk prediction of AD. |
| first_indexed | 2024-12-16T06:16:41Z |
| format | Article |
| id | doaj.art-0dc0cb283f4a4ffbaf9649541c5afec0 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-16T06:16:41Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-0dc0cb283f4a4ffbaf9649541c5afec02022-12-21T22:41:15ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-07-011110.3389/fnhum.2017.00380271340Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual AnalysesVahab Youssofzadeh0Vahab Youssofzadeh1Bernadette McGuinness2Liam P. Maguire3KongFatt Wong-Lin4Computational Neuroscience Research Team, Intelligent Systems Research Centre, School of Computing and Intelligent Systems, Faculty of Computing and Engineering, Ulster UniversityLondonderry, United KingdomDivision of Neurology, Cincinnati Children’s Hospital Medical CenterCincinnati, OH, United StatesInstitute of Clinical Science B, Centre for Public Health, Queen’s University BelfastBelfast, United KingdomComputational Neuroscience Research Team, Intelligent Systems Research Centre, School of Computing and Intelligent Systems, Faculty of Computing and Engineering, Ulster UniversityLondonderry, United KingdomComputational Neuroscience Research Team, Intelligent Systems Research Centre, School of Computing and Intelligent Systems, Faculty of Computing and Engineering, Ulster UniversityLondonderry, United KingdomMagnetic resonance imaging (MRI) and positron emission tomography (PET) are neuroimaging modalities typically used for evaluating brain changes in Alzheimer’s disease (AD). Due to their complementary nature, their combination can provide more accurate AD diagnosis or prognosis. In this work, we apply a multi-modal imaging machine-learning framework to enhance AD classification and prediction of diagnosis of subject-matched gray matter MRI and Pittsburgh compound B (PiB)-PET data related to 58 AD, 108 mild cognitive impairment (MCI) and 120 healthy elderly (HE) subjects from the Australian imaging, biomarkers and lifestyle (AIBL) dataset. Specifically, we combined a Dartel algorithm to enhance anatomical registration with multi-kernel learning (MKL) technique, yielding an average of >95% accuracy for three binary classification problems: AD-vs.-HE, MCI-vs.-HE and AD-vs.-MCI, a considerable improvement from individual modality approach. Consistent with t-contrasts, the MKL weight maps revealed known brain regions associated with AD, i.e., (para)hippocampus, posterior cingulate cortex and bilateral temporal gyrus. Importantly, MKL regression analysis provided excellent predictions of diagnosis of individuals by r2 = 0.86. In addition, we found significant correlations between the MKL classification and delayed memory recall scores with r2 = 0.62 (p < 0.01). Interestingly, outliers in the regression model for diagnosis were mainly converter samples with a higher likelihood of converting to the inclined diagnostic category. Overall, our work demonstrates the successful application of MKL with Dartel on combined neuromarkers from different neuroimaging modalities in the AIBL data. This lends further support in favor of machine learning approach in improving the diagnosis and risk prediction of AD.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00380/fullAlzheimer’s diseaseclassificationmachine learningmulti-kernel learningpredictionAustralian imaging |
| spellingShingle | Vahab Youssofzadeh Vahab Youssofzadeh Bernadette McGuinness Liam P. Maguire KongFatt Wong-Lin Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses Frontiers in Human Neuroscience Alzheimer’s disease classification machine learning multi-kernel learning prediction Australian imaging |
| title | Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses |
| title_full | Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses |
| title_fullStr | Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses |
| title_full_unstemmed | Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses |
| title_short | Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer’s Disease in AIBL Data: Group and Individual Analyses |
| title_sort | multi kernel learning with dartel improves combined mri pet classification of alzheimer s disease in aibl data group and individual analyses |
| topic | Alzheimer’s disease classification machine learning multi-kernel learning prediction Australian imaging |
| url | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00380/full |
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