Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue
In tissue regeneration, biomaterials facilitate biological processes. However, a treatment with biomaterials will be successful only if supported by simple and inexpensive technologies which stimulate the regenerative processes. The present study focused on the possibility of creating formulations f...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | ChemEngineering |
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| Online Access: | https://www.mdpi.com/2305-7084/6/1/10 |
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| author | Antonio Minó Giuseppe Cinelli Gianluca Paventi Gianluca Testa Fabiana Passaro Francesco Lopez Luigi Ambrosone |
| author_facet | Antonio Minó Giuseppe Cinelli Gianluca Paventi Gianluca Testa Fabiana Passaro Francesco Lopez Luigi Ambrosone |
| author_sort | Antonio Minó |
| collection | DOAJ |
| description | In tissue regeneration, biomaterials facilitate biological processes. However, a treatment with biomaterials will be successful only if supported by simple and inexpensive technologies which stimulate the regenerative processes. The present study focused on the possibility of creating formulations from which then to obtain suitable materials for the regeneration of heart tissue. The experimental procedure for precipitation of polymer- nanoparticles was modified ad hoc to obtain hybrid poly lactic-co-glycolic acid (PLGA)-phospholipid nanoparticles. The properties of the formulations produced by direct PLGA-phospholipid co-precipitation depend on the mass ratio <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="script">R</mi><mo>=</mo></mrow></semantics></math></inline-formula> polymer mass/phospholipid mass. The value of this parameter allows us to modulate the properties of the formulations. Formulations with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">R</mi></semantics></math></inline-formula> = 1.5, 2.3, 4, and 9 were prepared, and for each of them the particle-size distribution obtained by dynamic light scattering was studied. All samples showed that the hydrodynamic diameter decreases with increasing <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">R</mi></semantics></math></inline-formula> value. This behavior is interpreted as polymer coil shrinkage due to contacts with the non-solvent. The spreadability and ease of obtaining thin sheets were evaluated for each formulation. The formulation with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="script">R</mi><mo>=</mo><mn>4</mn></mrow></semantics></math></inline-formula> resulted in a homogeneous and easily workable material in thin sheets. |
| first_indexed | 2024-03-09T22:18:51Z |
| format | Article |
| id | doaj.art-0dc0f572529b4d0ab7ec2cb7d1cd4d08 |
| institution | Directory Open Access Journal |
| issn | 2305-7084 |
| language | English |
| last_indexed | 2024-03-09T22:18:51Z |
| publishDate | 2022-01-01 |
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| spelling | doaj.art-0dc0f572529b4d0ab7ec2cb7d1cd4d082023-11-23T19:16:45ZengMDPI AGChemEngineering2305-70842022-01-01611010.3390/chemengineering6010010Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological TissueAntonio Minó0Giuseppe Cinelli1Gianluca Paventi2Gianluca Testa3Fabiana Passaro4Francesco Lopez5Luigi Ambrosone6Department of Biosciences and Territory (DiBT), University of Molise, Contrada Lappone, 86090 Pesche, ItalyDipartimento di Agricoltura Ambiente Alimenti (DiAAA), University of Molise, Via F. De Sanctis snc, 86100 Campobasso, ItalyDepartment of Medicine and Health Sciences “V. Tiberio”, University of Molise, Via F. De Sanctis snc, 86100 Campobasso, ItalyDepartment of Medicine and Health Sciences “V. Tiberio”, University of Molise, Via F. De Sanctis snc, 86100 Campobasso, ItalyDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Via Pansini, 5, 80131 Napoli, ItalyDipartimento di Agricoltura Ambiente Alimenti (DiAAA), University of Molise, Via F. De Sanctis snc, 86100 Campobasso, ItalyDepartment of Medicine and Health Sciences “V. Tiberio”, University of Molise, Via F. De Sanctis snc, 86100 Campobasso, ItalyIn tissue regeneration, biomaterials facilitate biological processes. However, a treatment with biomaterials will be successful only if supported by simple and inexpensive technologies which stimulate the regenerative processes. The present study focused on the possibility of creating formulations from which then to obtain suitable materials for the regeneration of heart tissue. The experimental procedure for precipitation of polymer- nanoparticles was modified ad hoc to obtain hybrid poly lactic-co-glycolic acid (PLGA)-phospholipid nanoparticles. The properties of the formulations produced by direct PLGA-phospholipid co-precipitation depend on the mass ratio <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="script">R</mi><mo>=</mo></mrow></semantics></math></inline-formula> polymer mass/phospholipid mass. The value of this parameter allows us to modulate the properties of the formulations. Formulations with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">R</mi></semantics></math></inline-formula> = 1.5, 2.3, 4, and 9 were prepared, and for each of them the particle-size distribution obtained by dynamic light scattering was studied. All samples showed that the hydrodynamic diameter decreases with increasing <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="script">R</mi></semantics></math></inline-formula> value. This behavior is interpreted as polymer coil shrinkage due to contacts with the non-solvent. The spreadability and ease of obtaining thin sheets were evaluated for each formulation. The formulation with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="script">R</mi><mo>=</mo><mn>4</mn></mrow></semantics></math></inline-formula> resulted in a homogeneous and easily workable material in thin sheets.https://www.mdpi.com/2305-7084/6/1/10nanoparticlesPLGApatchphospholipids |
| spellingShingle | Antonio Minó Giuseppe Cinelli Gianluca Paventi Gianluca Testa Fabiana Passaro Francesco Lopez Luigi Ambrosone Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue ChemEngineering nanoparticles PLGA patch phospholipids |
| title | Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue |
| title_full | Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue |
| title_fullStr | Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue |
| title_full_unstemmed | Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue |
| title_short | Poly(Lactic-co-glycolic) Acid and Phospholipids Hybrid Nanoparticles for Regeneration of Biological Tissue |
| title_sort | poly lactic co glycolic acid and phospholipids hybrid nanoparticles for regeneration of biological tissue |
| topic | nanoparticles PLGA patch phospholipids |
| url | https://www.mdpi.com/2305-7084/6/1/10 |
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