The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation
Introduction: Rats exposed to angiotensin II (AII) receptor antagonists during lactation present progressive disturbances in renal development that lead to progressive alterations in renal function and structure. This study evaluates the role of oxidative stress in the renal changes induced by expos...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2014-12-01
|
| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312474049 |
| _version_ | 1797288946866061312 |
|---|---|
| author | Evelyn Cristina Santana Marin Heloísa Della Coletta Francescato Roberto Silva Costa Cleonice Giovanini Alves da Silva Terezila Machado Coimbra |
| author_facet | Evelyn Cristina Santana Marin Heloísa Della Coletta Francescato Roberto Silva Costa Cleonice Giovanini Alves da Silva Terezila Machado Coimbra |
| author_sort | Evelyn Cristina Santana Marin |
| collection | DOAJ |
| description | Introduction: Rats exposed to angiotensin II (AII) receptor antagonists during lactation present progressive disturbances in renal development that lead to progressive alterations in renal function and structure. This study evaluates the role of oxidative stress in the renal changes induced by exposure to losartan, a type 1 AII receptor antagonist, in rats during lactation. Materials and methods: Male Wistar pups were divided into: Control, pups of dams that received 2% sucrose solution; Control-tempol, pups of dams that received tempol (0.34 g/l), a superoxide dismutase mimetic compound; Losartan, pups of dams that received losartan (100 mg/kg/day), and Losartan-tempol, pups of dams that received losartan and tempol. Losartan and/or tempol were administered during lactation. Blood and urine samples were collected at 21 or 60 days, and the kidneys were removed. Results: Losartan-treated pups exhibited disturbances in renal function and structure that persisted into adulthood. Tempol treatment reduced oxidative stress and attenuated the changes induced by losartan in the glomerular filtration rate, desmin expression at the glomerular edge, vimentin in tubular cells, as well as apoptosis and inflammatory infiltration in the renal cortex. Conclusion: Oxidative stress contributes at least in part to the renal injury observed in pups exposed to losartan during lactation. |
| first_indexed | 2024-03-07T18:57:02Z |
| format | Article |
| id | doaj.art-0dc125b17e8c4672980adae836213a98 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:57:02Z |
| publishDate | 2014-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-0dc125b17e8c4672980adae836213a982024-03-02T00:08:16ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-12-011510.1177/1470320312474049The role of oxidative stress in renal injury induced in rats by losartan exposure during lactationEvelyn Cristina Santana Marin0Heloísa Della Coletta Francescato1Roberto Silva Costa2Cleonice Giovanini Alves da Silva3Terezila Machado Coimbra4Department of Physiology, School of Medicine of Ribeirão Preto, BrazilDepartment of Physiology, School of Medicine of Ribeirão Preto, BrazilDepartment of Pathology, School of Medicine of Ribeirão Preto, BrazilDepartment of Physiology, School of Medicine of Ribeirão Preto, BrazilDepartment of Physiology, School of Medicine of Ribeirão Preto, BrazilIntroduction: Rats exposed to angiotensin II (AII) receptor antagonists during lactation present progressive disturbances in renal development that lead to progressive alterations in renal function and structure. This study evaluates the role of oxidative stress in the renal changes induced by exposure to losartan, a type 1 AII receptor antagonist, in rats during lactation. Materials and methods: Male Wistar pups were divided into: Control, pups of dams that received 2% sucrose solution; Control-tempol, pups of dams that received tempol (0.34 g/l), a superoxide dismutase mimetic compound; Losartan, pups of dams that received losartan (100 mg/kg/day), and Losartan-tempol, pups of dams that received losartan and tempol. Losartan and/or tempol were administered during lactation. Blood and urine samples were collected at 21 or 60 days, and the kidneys were removed. Results: Losartan-treated pups exhibited disturbances in renal function and structure that persisted into adulthood. Tempol treatment reduced oxidative stress and attenuated the changes induced by losartan in the glomerular filtration rate, desmin expression at the glomerular edge, vimentin in tubular cells, as well as apoptosis and inflammatory infiltration in the renal cortex. Conclusion: Oxidative stress contributes at least in part to the renal injury observed in pups exposed to losartan during lactation.https://doi.org/10.1177/1470320312474049 |
| spellingShingle | Evelyn Cristina Santana Marin Heloísa Della Coletta Francescato Roberto Silva Costa Cleonice Giovanini Alves da Silva Terezila Machado Coimbra The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation Journal of the Renin-Angiotensin-Aldosterone System |
| title | The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation |
| title_full | The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation |
| title_fullStr | The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation |
| title_full_unstemmed | The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation |
| title_short | The role of oxidative stress in renal injury induced in rats by losartan exposure during lactation |
| title_sort | role of oxidative stress in renal injury induced in rats by losartan exposure during lactation |
| url | https://doi.org/10.1177/1470320312474049 |
| work_keys_str_mv | AT evelyncristinasantanamarin theroleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT heloisadellacolettafrancescato theroleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT robertosilvacosta theroleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT cleonicegiovaninialvesdasilva theroleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT terezilamachadocoimbra theroleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT evelyncristinasantanamarin roleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT heloisadellacolettafrancescato roleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT robertosilvacosta roleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT cleonicegiovaninialvesdasilva roleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation AT terezilamachadocoimbra roleofoxidativestressinrenalinjuryinducedinratsbylosartanexposureduringlactation |