Hypothermia impairs glymphatic drainage in traumatic brain injury as assessed by dynamic contrast-enhanced MRI with intrathecal contrast

Hypothermia impairs glymphatic drainage in traumatic brain injury as assessed by dynamic contrast-enhanced MRI with intrathecal contrast

IntroductionThe impact of hypothermia on the impaired drainage function of the glymphatic system in traumatic brain injury (TBI) is not understood.MethodsMale Sprague–Dawley rats undergoing controlled cortical impact injury (CCI) were subjected to hypothermia or normothermia treatment. The rats unde...

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Bibliographic Details
Main Authors: Wenquan Gu, Yingnan Bai, Jianguo Cai, Honglan Mi, Yinghui Bao, Xinxin Zhao, Chen Lu, Fengchen Zhang, Yue-hua Li, Qing Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neuroscience
Subjects:
hypothermia (HT)
traumatic brain injury
glymphatic function
magnetic resonance imaging (MRI)
contrast agent
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1061039/full

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