Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions

Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication. Neutrophils are highly versatile cells, which play a crucial role in the induction as well as the reso...

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Bibliographic Details
Main Authors: Endalew Yizengaw, Mulusew Getahun, Fitsumbrhan Tajebe, Edward Cruz Cervera, Getnet Mesfin, Emebet Adem, Asrat Hailu, Gert Van der Auwera, Vanessa Yardley, Mulualem Lemma, Ziv Skhedy, Ermias Diro, Arega Yeshanew, Roma Melkamu, Bewketu Mengesha, Manuel Modolell, Markus Munder, Ingrid Muller, Yegnasew Teferi, Pascale Kropf
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Leishmania
Neutrophils
Phagocytosis
Reactive Oxygen Species
Visceral leishmaniasis
neutrophil extracellular traps
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00517/full

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