Iterative Restoration of the Fringe Phase (REFRASE) for QSM
In quantitative susceptibility mapping (QSM), reconstructed results can be critically biased by misinterpreted or missing phase data near the edges of the brain support originating from the non-local relationship between field and susceptibility. These data either have to be excluded or corrected be...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.537666/full |
| _version_ | 1818663430811287552 |
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| author | Johannes Lindemeyer Wieland A. Worthoff Aliaksandra Shymanskaya N. Jon Shah N. Jon Shah N. Jon Shah N. Jon Shah |
| author_facet | Johannes Lindemeyer Wieland A. Worthoff Aliaksandra Shymanskaya N. Jon Shah N. Jon Shah N. Jon Shah N. Jon Shah |
| author_sort | Johannes Lindemeyer |
| collection | DOAJ |
| description | In quantitative susceptibility mapping (QSM), reconstructed results can be critically biased by misinterpreted or missing phase data near the edges of the brain support originating from the non-local relationship between field and susceptibility. These data either have to be excluded or corrected before further processing can take place. To address this, our iterative restoration of the fringe phase (REFRASE) approach simultaneously enhances the accuracy of multi-echo phase data QSM maps and the extent of the area available for evaluation. Data loss caused by strong local phase gradients near the surface of the brain support is recovered within the original phase data using harmonic and dipole-based fields extrapolated from a robust support region toward an extended brain mask. Over several iterations, phase data are rectified prior to the application of further QSM processing steps. The concept is successfully validated on numerical phantoms and brain scans from a cohort of volunteers. The increased extent of the mask and improved numerical stability within the segmented globus pallidus confirm the efficacy of the presented method in comparison to traditional evaluation. |
| first_indexed | 2024-12-17T05:16:44Z |
| format | Article |
| id | doaj.art-0dc68d7b04cb42259a36acea88fa517b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-17T05:16:44Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0dc68d7b04cb42259a36acea88fa517b2022-12-21T22:02:05ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-05-011510.3389/fnins.2021.537666537666Iterative Restoration of the Fringe Phase (REFRASE) for QSMJohannes Lindemeyer0Wieland A. Worthoff1Aliaksandra Shymanskaya2N. Jon Shah3N. Jon Shah4N. Jon Shah5N. Jon Shah6Institute of Neuroscience and Medicine–4, Forschungszentrum Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine–4, Forschungszentrum Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine–11, Forschungszentrum Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine–4, Forschungszentrum Jülich, Jülich, GermanyInstitute of Neuroscience and Medicine–11, Forschungszentrum Jülich, Jülich, GermanyJARA–BRAIN–Translational Medicine, Aachen, GermanyDepartment of Neurology, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, GermanyIn quantitative susceptibility mapping (QSM), reconstructed results can be critically biased by misinterpreted or missing phase data near the edges of the brain support originating from the non-local relationship between field and susceptibility. These data either have to be excluded or corrected before further processing can take place. To address this, our iterative restoration of the fringe phase (REFRASE) approach simultaneously enhances the accuracy of multi-echo phase data QSM maps and the extent of the area available for evaluation. Data loss caused by strong local phase gradients near the surface of the brain support is recovered within the original phase data using harmonic and dipole-based fields extrapolated from a robust support region toward an extended brain mask. Over several iterations, phase data are rectified prior to the application of further QSM processing steps. The concept is successfully validated on numerical phantoms and brain scans from a cohort of volunteers. The increased extent of the mask and improved numerical stability within the segmented globus pallidus confirm the efficacy of the presented method in comparison to traditional evaluation.https://www.frontiersin.org/articles/10.3389/fnins.2021.537666/fullmagnetic resonance imagingphase imagingfield mappingbackground field removalquantitative susceptibility mapping |
| spellingShingle | Johannes Lindemeyer Wieland A. Worthoff Aliaksandra Shymanskaya N. Jon Shah N. Jon Shah N. Jon Shah N. Jon Shah Iterative Restoration of the Fringe Phase (REFRASE) for QSM Frontiers in Neuroscience magnetic resonance imaging phase imaging field mapping background field removal quantitative susceptibility mapping |
| title | Iterative Restoration of the Fringe Phase (REFRASE) for QSM |
| title_full | Iterative Restoration of the Fringe Phase (REFRASE) for QSM |
| title_fullStr | Iterative Restoration of the Fringe Phase (REFRASE) for QSM |
| title_full_unstemmed | Iterative Restoration of the Fringe Phase (REFRASE) for QSM |
| title_short | Iterative Restoration of the Fringe Phase (REFRASE) for QSM |
| title_sort | iterative restoration of the fringe phase refrase for qsm |
| topic | magnetic resonance imaging phase imaging field mapping background field removal quantitative susceptibility mapping |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.537666/full |
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