Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome
Abstract Pathophysiological mechanisms of peripartum cardiomyopathy are not yet completely defined, although there is a strong association with various factors that are already known, including pre-eclampsia. Peripartum cardiomyopathy treatment follows the same recommendations as heart failure with...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2016-06-01
|
| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016000600308&tlng=en |
| _version_ | 1818950942094000128 |
|---|---|
| author | Maria Adélia Medeiros e Melo Jordão Sousa Carvalho Francisco Edson de Lucena Feitosa Edward Araujo Júnior Alberto Borges Peixoto Francisco Herlânio Costa Carvalho Regina Coeli Marques Carvalho |
| author_facet | Maria Adélia Medeiros e Melo Jordão Sousa Carvalho Francisco Edson de Lucena Feitosa Edward Araujo Júnior Alberto Borges Peixoto Francisco Herlânio Costa Carvalho Regina Coeli Marques Carvalho |
| author_sort | Maria Adélia Medeiros e Melo |
| collection | DOAJ |
| description | Abstract Pathophysiological mechanisms of peripartum cardiomyopathy are not yet completely defined, although there is a strong association with various factors that are already known, including pre-eclampsia. Peripartum cardiomyopathy treatment follows the same recommendations as heart failure with systolic dysfunction. Clinical and experimental studies suggest that products of prolactin degradation can induce this cardiomyopathy. The pharmacological suppression of prolactin production by D2 dopamine receptor agonists bromocriptine and cabergoline has demonstrated satisfactory results in the therapeutic response to the treatment. Here we present a case of an adolescent patient in her first gestation with peripartum cardiomyopathy that evolved to the normalized left ventricular function after cabergoline administration, which was used as an adjuvant in cardiac dysfunction treatment. Subsequently, despite a short interval between pregnancies, the patient exhibited satisfactory progress throughout the entire gestation or puerperium in a new pregnancy without any cardiac alterations. Dopamine agonists that are orally used and are affordable in most tertiary centers, particularly in developing countries, should be considered when treating peripartum cardiomyopathy cases. |
| first_indexed | 2024-12-20T09:26:36Z |
| format | Article |
| id | doaj.art-0dc6ddaf88bb40879ba8f69d03868b36 |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-12-20T09:26:36Z |
| publishDate | 2016-06-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-0dc6ddaf88bb40879ba8f69d03868b362022-12-21T19:45:10ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032016-06-0138630831310.1055/s-0036-1584567Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory OutcomeMaria Adélia Medeiros e MeloJordão Sousa CarvalhoFrancisco Edson de Lucena FeitosaEdward Araujo JúniorAlberto Borges PeixotoFrancisco Herlânio Costa CarvalhoRegina Coeli Marques CarvalhoAbstract Pathophysiological mechanisms of peripartum cardiomyopathy are not yet completely defined, although there is a strong association with various factors that are already known, including pre-eclampsia. Peripartum cardiomyopathy treatment follows the same recommendations as heart failure with systolic dysfunction. Clinical and experimental studies suggest that products of prolactin degradation can induce this cardiomyopathy. The pharmacological suppression of prolactin production by D2 dopamine receptor agonists bromocriptine and cabergoline has demonstrated satisfactory results in the therapeutic response to the treatment. Here we present a case of an adolescent patient in her first gestation with peripartum cardiomyopathy that evolved to the normalized left ventricular function after cabergoline administration, which was used as an adjuvant in cardiac dysfunction treatment. Subsequently, despite a short interval between pregnancies, the patient exhibited satisfactory progress throughout the entire gestation or puerperium in a new pregnancy without any cardiac alterations. Dopamine agonists that are orally used and are affordable in most tertiary centers, particularly in developing countries, should be considered when treating peripartum cardiomyopathy cases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016000600308&tlng=enperipartum cardiomyopathycongestive heart failuredopamine agonistspregnancy outcome |
| spellingShingle | Maria Adélia Medeiros e Melo Jordão Sousa Carvalho Francisco Edson de Lucena Feitosa Edward Araujo Júnior Alberto Borges Peixoto Francisco Herlânio Costa Carvalho Regina Coeli Marques Carvalho Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome Revista Brasileira de Ginecologia e Obstetrícia peripartum cardiomyopathy congestive heart failure dopamine agonists pregnancy outcome |
| title | Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome |
| title_full | Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome |
| title_fullStr | Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome |
| title_full_unstemmed | Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome |
| title_short | Peripartum Cardiomyopathy Treatment with Dopamine Agonist and Subsequent Pregnancy with a Satisfactory Outcome |
| title_sort | peripartum cardiomyopathy treatment with dopamine agonist and subsequent pregnancy with a satisfactory outcome |
| topic | peripartum cardiomyopathy congestive heart failure dopamine agonists pregnancy outcome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032016000600308&tlng=en |
| work_keys_str_mv | AT mariaadeliamedeirosemelo peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome AT jordaosousacarvalho peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome AT franciscoedsondelucenafeitosa peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome AT edwardaraujojunior peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome AT albertoborgespeixoto peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome AT franciscoherlaniocostacarvalho peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome AT reginacoelimarquescarvalho peripartumcardiomyopathytreatmentwithdopamineagonistandsubsequentpregnancywithasatisfactoryoutcome |