A structure-based drug design approach for the identification of antiviral compounds targeting the chikungunya virus RdRp protein

A structure-based drug design approach for the identification of antiviral compounds targeting the chikungunya virus RdRp protein

There are an estimated 3 million Chikungunya virus (CHIKV) infections per year, but no vaccines or specific pharmaceutical treatments are available. RNA-dependent RNA polymerase (RdRp) of CHIKV, encoded by nonstructural protein 4 (nsP4), was targeted to identify potential antiviral compounds in this...

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Bibliographic Details
Main Authors: Md. Hridoy Ahmed, Gagandeep Singh, Melvin Castrosanto, Alomgir Hossain, Md. Morshedul Islam Rifat, Sadia Hosna Rima, Vandana Gupta, Rajesh K. Kesharwani, Mariusz Jaremko, Abdul-Hamid Emwas, Prawez Alam, Faizul Azam
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Chemical Physics Impact
Subjects:
Chikungunya
Homology modeling
E-pharmacophore
Molecular docking
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S266702242300289X

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