Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds
White adipose tissue expands rapidly due to increased adipocyte number (hyperplasia) and size (hypertrophy), which results in obesity. Adipogenesis is a process of the formation of mature adipocytes from precursor cells. Additionally, obesity-related metabolic complications, such as fatty liver and...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011040 |
| _version_ | 1811237590514270208 |
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| author | Faizullah Khan Haroon Khan Ajmal Khan Masao Yamasaki Naima Moustaid-Moussa Ahmed Al-Harrasi Shaikh Mizanoor Rahman |
| author_facet | Faizullah Khan Haroon Khan Ajmal Khan Masao Yamasaki Naima Moustaid-Moussa Ahmed Al-Harrasi Shaikh Mizanoor Rahman |
| author_sort | Faizullah Khan |
| collection | DOAJ |
| description | White adipose tissue expands rapidly due to increased adipocyte number (hyperplasia) and size (hypertrophy), which results in obesity. Adipogenesis is a process of the formation of mature adipocytes from precursor cells. Additionally, obesity-related metabolic complications, such as fatty liver and insulin resistance, are linked to adipogenesis. On the contrary, autophagy is a catabolic process; essential to maintain cellular homeostasis via the degradation or recycling of unnecessary or damaged components. Importantly, autophagy dictates obesity and adipogenesis. Hence, a clear understanding of how autophagy regulates adipogenesis is crucial for drug development and the prevention and treatment of obesity and its associated disorders, such as type 2 diabetes, cardiovascular disease, and cancer. In this review, we highlighted recent findings regarding the crosstalk between adipogenesis and autophagy, as well as the molecules involved. Furthermore, the review discussed how bioactive compounds regulate adipogenesis by manipulating autophagy and underlying molecular mechanisms. Based on in vitro and animal studies, we summarized the effects of bioactive compounds on adipogenesis and autophagy. Hence, human studies are necessary to validate the effectiveness and optimal dosage of these bioactive compounds. |
| first_indexed | 2024-04-12T12:27:13Z |
| format | Article |
| id | doaj.art-0dc81c093183491fae70dc551809bd59 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T12:27:13Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-0dc81c093183491fae70dc551809bd592022-12-22T03:33:08ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113715Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compoundsFaizullah Khan0Haroon Khan1Ajmal Khan2Masao Yamasaki3Naima Moustaid-Moussa4Ahmed Al-Harrasi5Shaikh Mizanoor Rahman6Natural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Sultanate of Oman; Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200 Khyber Pakhtunkhwa, PakistanDepartment of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200 Khyber Pakhtunkhwa, PakistanNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Sultanate of OmanDepartment of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, JapanTexas Tech University, Nutritional Sciences, Lubbock, TX 79409, USA; Obesity Research Institute, Texas Tech University, Lubbock, TX 79409, USANatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Sultanate of OmanNatural and Medical Sciences Research Center, University of Nizwa, Nizwa 616, Sultanate of Oman; Correspondence to: Natural & Medical Sciences Research Center, University of Nizwa, Sultanate of Oman.White adipose tissue expands rapidly due to increased adipocyte number (hyperplasia) and size (hypertrophy), which results in obesity. Adipogenesis is a process of the formation of mature adipocytes from precursor cells. Additionally, obesity-related metabolic complications, such as fatty liver and insulin resistance, are linked to adipogenesis. On the contrary, autophagy is a catabolic process; essential to maintain cellular homeostasis via the degradation or recycling of unnecessary or damaged components. Importantly, autophagy dictates obesity and adipogenesis. Hence, a clear understanding of how autophagy regulates adipogenesis is crucial for drug development and the prevention and treatment of obesity and its associated disorders, such as type 2 diabetes, cardiovascular disease, and cancer. In this review, we highlighted recent findings regarding the crosstalk between adipogenesis and autophagy, as well as the molecules involved. Furthermore, the review discussed how bioactive compounds regulate adipogenesis by manipulating autophagy and underlying molecular mechanisms. Based on in vitro and animal studies, we summarized the effects of bioactive compounds on adipogenesis and autophagy. Hence, human studies are necessary to validate the effectiveness and optimal dosage of these bioactive compounds.http://www.sciencedirect.com/science/article/pii/S0753332222011040AdipogenesisAutophagyTranscription factorMolecular regulationBioactive compounds |
| spellingShingle | Faizullah Khan Haroon Khan Ajmal Khan Masao Yamasaki Naima Moustaid-Moussa Ahmed Al-Harrasi Shaikh Mizanoor Rahman Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds Biomedicine & Pharmacotherapy Adipogenesis Autophagy Transcription factor Molecular regulation Bioactive compounds |
| title | Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds |
| title_full | Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds |
| title_fullStr | Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds |
| title_full_unstemmed | Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds |
| title_short | Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds |
| title_sort | autophagy in adipogenesis molecular mechanisms and regulation by bioactive compounds |
| topic | Adipogenesis Autophagy Transcription factor Molecular regulation Bioactive compounds |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011040 |
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