Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases
Abstract Background The association between isolated maternal hypothyroxinemia (IMH) and adverse pregnancy outcomes is still controversial. This study aimed to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes in southern Chinese women. Methods This was a...
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BMC
2022-11-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-022-05194-w |
| _version_ | 1811186990307082240 |
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| author | Ping Li Jinhui Cui Ling Li Xinjuan Chen Liping Ouyang Jianhui Fan Shuo Lin |
| author_facet | Ping Li Jinhui Cui Ling Li Xinjuan Chen Liping Ouyang Jianhui Fan Shuo Lin |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Abstract Background The association between isolated maternal hypothyroxinemia (IMH) and adverse pregnancy outcomes is still controversial. This study aimed to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes in southern Chinese women. Methods This was a hospital-based, retrospective cohort study. The records of 7051 women, including 1337 IMH women and 5714 euthyroid women who had a singleton pregnancy and accepted routine prenatal service at the Third Affiliated Hospital of Sun Yat-Sen University from January 2015 to September 2018, were extracted from the electronic medical records system in this study. Thyroid functions [thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab)] had to be measured before 13 weeks and 6 days of gestation. The chi-square test and multivariate logistic regression analysis were applied to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes. Results Prepregnancy obesity [prepregnancy body mass index (preBMI) ≥ 25 kg/m2] was found to be more common in the IMH group (11.2% vs. 6.1%) (P < 0.05). The prevalence of gestational diabetes mellitus (GDM), postpartum haemorrhage (PPH), macrosomia and large for gestational age (LGA) was higher in the IMH group. However, after using multivariate logistic regression analysis to adjust for confounders (maternal age, educational levels and preBMI), only LGA was shown to be associated with an increased risk in IMH women [adjusted OR: 1.27 (95% CI 1.044–1.566)]. The prevalence of preterm delivery (either < 37 or < 34 weeks), gestational hypertension, preeclampsia, placenta previa, placental abruption, premature rupture of membrane (PROM), intrauterine growth restriction (IUGR), polyhydramnios, stillbirth, small for gestational age (SGA) and low Apgar score did not increase. Conclusion IMH during the first trimester did not increase any risk of adverse pregnancy outcomes in southern Chinese women except LGA. |
| first_indexed | 2024-04-11T13:55:37Z |
| format | Article |
| id | doaj.art-0dc87e31056949499d266e710187d74b |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-11T13:55:37Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-0dc87e31056949499d266e710187d74b2022-12-22T04:20:22ZengBMCBMC Pregnancy and Childbirth1471-23932022-11-012211910.1186/s12884-022-05194-wAssociation between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 casesPing Li0Jinhui Cui1Ling Li2Xinjuan Chen3Liping Ouyang4Jianhui Fan5Shuo Lin6Department of Obstetrics and Gynaecology, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Obstetrics and Gynaecology, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Obstetrics and Gynaecology, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Obstetrics and Gynaecology, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Obstetrics and Gynaecology, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Obstetrics and Gynaecology, Third Affiliated Hospital of Sun Yat-Sen UniversityDepartment of Endocrinology, Third Affiliated Hospital of Sun Yat-Sen UniversityAbstract Background The association between isolated maternal hypothyroxinemia (IMH) and adverse pregnancy outcomes is still controversial. This study aimed to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes in southern Chinese women. Methods This was a hospital-based, retrospective cohort study. The records of 7051 women, including 1337 IMH women and 5714 euthyroid women who had a singleton pregnancy and accepted routine prenatal service at the Third Affiliated Hospital of Sun Yat-Sen University from January 2015 to September 2018, were extracted from the electronic medical records system in this study. Thyroid functions [thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab)] had to be measured before 13 weeks and 6 days of gestation. The chi-square test and multivariate logistic regression analysis were applied to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes. Results Prepregnancy obesity [prepregnancy body mass index (preBMI) ≥ 25 kg/m2] was found to be more common in the IMH group (11.2% vs. 6.1%) (P < 0.05). The prevalence of gestational diabetes mellitus (GDM), postpartum haemorrhage (PPH), macrosomia and large for gestational age (LGA) was higher in the IMH group. However, after using multivariate logistic regression analysis to adjust for confounders (maternal age, educational levels and preBMI), only LGA was shown to be associated with an increased risk in IMH women [adjusted OR: 1.27 (95% CI 1.044–1.566)]. The prevalence of preterm delivery (either < 37 or < 34 weeks), gestational hypertension, preeclampsia, placenta previa, placental abruption, premature rupture of membrane (PROM), intrauterine growth restriction (IUGR), polyhydramnios, stillbirth, small for gestational age (SGA) and low Apgar score did not increase. Conclusion IMH during the first trimester did not increase any risk of adverse pregnancy outcomes in southern Chinese women except LGA.https://doi.org/10.1186/s12884-022-05194-wIsolated maternal hypothyroxinemiaAdverse pregnancy outcomesFirst trimester |
| spellingShingle | Ping Li Jinhui Cui Ling Li Xinjuan Chen Liping Ouyang Jianhui Fan Shuo Lin Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases BMC Pregnancy and Childbirth Isolated maternal hypothyroxinemia Adverse pregnancy outcomes First trimester |
| title | Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases |
| title_full | Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases |
| title_fullStr | Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases |
| title_full_unstemmed | Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases |
| title_short | Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases |
| title_sort | association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in southern chinese women a retrospective study of 7051 cases |
| topic | Isolated maternal hypothyroxinemia Adverse pregnancy outcomes First trimester |
| url | https://doi.org/10.1186/s12884-022-05194-w |
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