The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients
Objective: To determine the role of interleukin-24 as a pro-inflammatory cytokine among female rheumatoid arthritis patients, and its correlation with clinical parameters. Method: The case-control study was conducted from April to July 2021 at the Baghdad Teaching Hospital and Yarmouk Teaching Hosp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2023-10-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://ojs.jpma.org.pk/index.php/public_html/article/view/10819 |
| _version_ | 1797663516428075008 |
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| author | Sattar Brissm Hassan Hanaa Naji Abdullah Khaled Yassin Zakair |
| author_facet | Sattar Brissm Hassan Hanaa Naji Abdullah Khaled Yassin Zakair |
| author_sort | Sattar Brissm Hassan |
| collection | DOAJ |
| description |
Objective: To determine the role of interleukin-24 as a pro-inflammatory cytokine among female rheumatoid arthritis
patients, and its correlation with clinical parameters.
Method: The case-control study was conducted from April to July 2021 at the Baghdad Teaching Hospital and
Yarmouk Teaching Hospital, Iraq, and comprised women aged 26-60 years in the Al-Karkh district having rheumatoid
arthritis diagnosed by a rheumatologist, and healthy controls matched for age and gender. Data was analysed using
SPSS 28.
Results: Of the 118 subjects, 76(64.4%) were patients with mean age 45.38±1.23 years, and 42(35.6%) were controls
with mean age 46.48±2.02 years. Rheumatoid factor level was highly significant among the cases
37.30±2.50mg/L compared to the controls 4.91±0.53mg/L (p Less than or Equal to 0.05), and similar was the case with anti-cyclic
citrullinated peptides 63.04±2.82U/mL versus 14.02±0.30U/mL (p Less than or Equal to 0.05). Serum interleukin-24 was considerably
elevated in patients 157.52±9.40 compared to controls 34.75±3.06 (p Less than or Equal to 0.05). Interleukin-24 had a significant positive
correlation with rheumatoid factor, and a significant negative correlation with C-reactive protein and erythrocyte
sedimentation rate (p<0.05).
Conclusion: Patients with rheumatoid arthritis had higher interleukin-24 serum levels than healthy controls, indicating
that interleukin-24 may be a significant marker in rheumatoid arthritis diagnosis.
Keywords: Protein, Antibodies, Cytokines, Arthritis, Rheumatoid.
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| first_indexed | 2024-03-11T19:15:47Z |
| format | Article |
| id | doaj.art-0dcb1a7547c745c5a01da9de6dafe4af |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-11T19:15:47Z |
| publishDate | 2023-10-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-0dcb1a7547c745c5a01da9de6dafe4af2023-10-09T05:00:06ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-10-0173910.47391/JPMA.IQ-21The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patientsSattar Brissm Hassan0Hanaa Naji Abdullah1Khaled Yassin Zakair2College of the Health and Medical Techniques, Middle Technical University, Baghdad, IraqCollege of the Health and Medical Techniques, Middle Technical University, Baghdad, IraqCollege of the Health and Medical Techniques, Middle Technical University, Baghdad, Iraq Objective: To determine the role of interleukin-24 as a pro-inflammatory cytokine among female rheumatoid arthritis patients, and its correlation with clinical parameters. Method: The case-control study was conducted from April to July 2021 at the Baghdad Teaching Hospital and Yarmouk Teaching Hospital, Iraq, and comprised women aged 26-60 years in the Al-Karkh district having rheumatoid arthritis diagnosed by a rheumatologist, and healthy controls matched for age and gender. Data was analysed using SPSS 28. Results: Of the 118 subjects, 76(64.4%) were patients with mean age 45.38±1.23 years, and 42(35.6%) were controls with mean age 46.48±2.02 years. Rheumatoid factor level was highly significant among the cases 37.30±2.50mg/L compared to the controls 4.91±0.53mg/L (p Less than or Equal to 0.05), and similar was the case with anti-cyclic citrullinated peptides 63.04±2.82U/mL versus 14.02±0.30U/mL (p Less than or Equal to 0.05). Serum interleukin-24 was considerably elevated in patients 157.52±9.40 compared to controls 34.75±3.06 (p Less than or Equal to 0.05). Interleukin-24 had a significant positive correlation with rheumatoid factor, and a significant negative correlation with C-reactive protein and erythrocyte sedimentation rate (p<0.05). Conclusion: Patients with rheumatoid arthritis had higher interleukin-24 serum levels than healthy controls, indicating that interleukin-24 may be a significant marker in rheumatoid arthritis diagnosis. Keywords: Protein, Antibodies, Cytokines, Arthritis, Rheumatoid. https://ojs.jpma.org.pk/index.php/public_html/article/view/10819 |
| spellingShingle | Sattar Brissm Hassan Hanaa Naji Abdullah Khaled Yassin Zakair The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients Journal of the Pakistan Medical Association |
| title | The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients |
| title_full | The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients |
| title_fullStr | The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients |
| title_full_unstemmed | The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients |
| title_short | The role of IL-24 as a pro-inflammatory cytokine in some Iraqi rheumatoid arthritis patients |
| title_sort | role of il 24 as a pro inflammatory cytokine in some iraqi rheumatoid arthritis patients |
| url | https://ojs.jpma.org.pk/index.php/public_html/article/view/10819 |
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