Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome
Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical course of the disease is characterized by frequent...
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/6993 |
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| author | Andrzej Badeński Marta Badeńska Elżbieta Świętochowska Artur Janek Aleksandra Gliwińska Aurelia Morawiec-Knysak Maria Szczepańska |
| author_facet | Andrzej Badeński Marta Badeńska Elżbieta Świętochowska Artur Janek Aleksandra Gliwińska Aurelia Morawiec-Knysak Maria Szczepańska |
| author_sort | Andrzej Badeński |
| collection | DOAJ |
| description | Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical course of the disease is characterized by frequent relapses. Interleukin-15 (IL-15) is a pro-inflammatory cytokine, that apart from its involvement in the immune system, was found to be playing a vital role in various cells’ functioning, including renal tissue. It is desirable to look for new predictors of INS. Our study aimed to evaluate IL-15 as a potential marker in the early diagnosis of the disease. The cohort participating in the study consisted of patients hospitalized in Clinical Hospital No. 1 in Zabrze, from December 2019 to December 2021, including study group with INS (<i>n</i> = 30) and control group (<i>n</i> = 44). Results: The concentration of IL-15 in both serum and urine was significantly elevated in patients with INS, compared to healthy controls. The cytokine might serve as a marker of the disease, however, further research on larger study groups is needed. |
| first_indexed | 2024-03-11T04:56:46Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:46Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0dcb7dd36bee456a889f35a594d4a1902023-11-17T19:33:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248699310.3390/ijms24086993Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic SyndromeAndrzej Badeński0Marta Badeńska1Elżbieta Świętochowska2Artur Janek3Aleksandra Gliwińska4Aurelia Morawiec-Knysak5Maria Szczepańska6Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, PolandDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze-Rokitnica, PolandDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, PolandDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, PolandDepartment of Pediatric Nephrology with Dialysis Division for Children, Public Clinical Hospital No. 1 in Zabrze, ul. 3 Maja 13/15, 41-800 Zabrze, PolandDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, PolandIdiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children, characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema and hyperlipidemia. The pathogenesis, however, has not been yet established. The clinical course of the disease is characterized by frequent relapses. Interleukin-15 (IL-15) is a pro-inflammatory cytokine, that apart from its involvement in the immune system, was found to be playing a vital role in various cells’ functioning, including renal tissue. It is desirable to look for new predictors of INS. Our study aimed to evaluate IL-15 as a potential marker in the early diagnosis of the disease. The cohort participating in the study consisted of patients hospitalized in Clinical Hospital No. 1 in Zabrze, from December 2019 to December 2021, including study group with INS (<i>n</i> = 30) and control group (<i>n</i> = 44). Results: The concentration of IL-15 in both serum and urine was significantly elevated in patients with INS, compared to healthy controls. The cytokine might serve as a marker of the disease, however, further research on larger study groups is needed.https://www.mdpi.com/1422-0067/24/8/6993idiopathic nephrotic syndromeIL-15childrenmarker |
| spellingShingle | Andrzej Badeński Marta Badeńska Elżbieta Świętochowska Artur Janek Aleksandra Gliwińska Aurelia Morawiec-Knysak Maria Szczepańska Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome International Journal of Molecular Sciences idiopathic nephrotic syndrome IL-15 children marker |
| title | Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome |
| title_full | Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome |
| title_fullStr | Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome |
| title_full_unstemmed | Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome |
| title_short | Assessment of Interleukin-15 (IL-15) Concentration in Children with Idiopathic Nephrotic Syndrome |
| title_sort | assessment of interleukin 15 il 15 concentration in children with idiopathic nephrotic syndrome |
| topic | idiopathic nephrotic syndrome IL-15 children marker |
| url | https://www.mdpi.com/1422-0067/24/8/6993 |
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