Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products
Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemi...
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| Format: | Article |
| Language: | English |
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International Association of Physical Chemists (IAPC)
2019-05-01
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| Series: | Journal of Electrochemical Science and Engineering |
| Subjects: | |
| Online Access: | http://pub.iapchem.org/ojs/index.php/JESE/article/view/652 |
| _version_ | 1818177384077066240 |
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| author | Faraja Ombwayo Zahilis Mazzhichette Amos Mugweru |
| author_facet | Faraja Ombwayo Zahilis Mazzhichette Amos Mugweru |
| author_sort | Faraja Ombwayo |
| collection | DOAJ |
| description | Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin. |
| first_indexed | 2024-12-11T20:31:13Z |
| format | Article |
| id | doaj.art-0dcbb9c5297d4108a4668c5237c85f0d |
| institution | Directory Open Access Journal |
| issn | 1847-9286 |
| language | English |
| last_indexed | 2024-12-11T20:31:13Z |
| publishDate | 2019-05-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | Journal of Electrochemical Science and Engineering |
| spelling | doaj.art-0dcbb9c5297d4108a4668c5237c85f0d2022-12-22T00:51:49ZengInternational Association of Physical Chemists (IAPC)Journal of Electrochemical Science and Engineering1847-92862019-05-019310.5599/jese.652367Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis productsFaraja Ombwayo0Zahilis Mazzhichette1Amos Mugweru2Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.http://pub.iapchem.org/ojs/index.php/JESE/article/view/652Cyclic voltammetrydyhidroartemisininelectrochemical reductionbulk electrolysisLC-MS |
| spellingShingle | Faraja Ombwayo Zahilis Mazzhichette Amos Mugweru Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products Journal of Electrochemical Science and Engineering Cyclic voltammetry dyhidroartemisinin electrochemical reduction bulk electrolysis LC-MS |
| title | Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products |
| title_full | Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products |
| title_fullStr | Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products |
| title_full_unstemmed | Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products |
| title_short | Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products |
| title_sort | electrochemical reduction of artemisinin chromatographic identification of bulk electrolysis products |
| topic | Cyclic voltammetry dyhidroartemisinin electrochemical reduction bulk electrolysis LC-MS |
| url | http://pub.iapchem.org/ojs/index.php/JESE/article/view/652 |
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