Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events
Abstract We aimed to clarify the relationship between apolipoprotein C3 (apo-C3) and the vascular composition of lesion plaque in stable coronary disease (SCD) before percutaneous coronary intervention (PCI), and to investigate major adverse cardiovascular events (MACEs) within 4 years. Data of 98 c...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-18914-1 |
| _version_ | 1818082405707153408 |
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| author | Takayuki Ohwada Takayuki Sakamoto Satoshi Suzuki Yukiko Sugawara Kazuya Sakamoto Ayano Ikeda Fumika Haga Tomoki Sato Kazuhiko Nakazato Yasuchika Takeishi Kenichi Watanabe |
| author_facet | Takayuki Ohwada Takayuki Sakamoto Satoshi Suzuki Yukiko Sugawara Kazuya Sakamoto Ayano Ikeda Fumika Haga Tomoki Sato Kazuhiko Nakazato Yasuchika Takeishi Kenichi Watanabe |
| author_sort | Takayuki Ohwada |
| collection | DOAJ |
| description | Abstract We aimed to clarify the relationship between apolipoprotein C3 (apo-C3) and the vascular composition of lesion plaque in stable coronary disease (SCD) before percutaneous coronary intervention (PCI), and to investigate major adverse cardiovascular events (MACEs) within 4 years. Data of 98 consecutive patients with SCD who underwent PCI between November 1, 2012, and March 10, 2015, were analyzed. Laboratory and virtual histology-intravascular ultrasound (VH-IVUS) examinations of culprit lesions were conducted before PCI. Patients were divided according to median apo-C3 into low apo-C3 (≤ 8.5 mg/dL) and high apo-C3 (> 8.5 mg/dL) groups. VH-IVUS data indicated that the percentage of necrotic core volume (%NC) was significantly higher in the high apo-C3 group than in the low apo-C3 group. Moreover, the %NC significantly correlated with the apo-C3 level (R = 0.2109, P = 0.037). Kaplan–Meier curve analysis revealed that freedom from MACEs exhibited a greater decrease in the high apo-C3 group than in the low apo-C3 group, and in the high %NC group than in the low %NC group. Multivariate Cox hazards analysis showed that the %NC and high apo-C3 were independent predictors of 4 year MACEs. Apo-C3 may be a useful marker of future MACEs in patients with SCD after PCI and contribute to %NC growth. |
| first_indexed | 2024-12-10T19:21:35Z |
| format | Article |
| id | doaj.art-0dceea9e674740f4986c1491d626ea5c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T19:21:35Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0dceea9e674740f4986c1491d626ea5c2022-12-22T01:36:28ZengNature PortfolioScientific Reports2045-23222022-08-011211910.1038/s41598-022-18914-1Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular eventsTakayuki Ohwada0Takayuki Sakamoto1Satoshi Suzuki2Yukiko Sugawara3Kazuya Sakamoto4Ayano Ikeda5Fumika Haga6Tomoki Sato7Kazuhiko Nakazato8Yasuchika Takeishi9Kenichi Watanabe10Department of Cardiology, Fukushima Red Cross HospitalDepartment of Cardiology, Fukushima Red Cross HospitalDepartment of Cardiology, Takeda General HospitalDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiology, Fukushima Red Cross HospitalDepartment of Cardiology, Fukushima Red Cross HospitalDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiovascular Medicine, Fukushima Medical UniversityDepartment of Cardiology, Fukushima Red Cross HospitalAbstract We aimed to clarify the relationship between apolipoprotein C3 (apo-C3) and the vascular composition of lesion plaque in stable coronary disease (SCD) before percutaneous coronary intervention (PCI), and to investigate major adverse cardiovascular events (MACEs) within 4 years. Data of 98 consecutive patients with SCD who underwent PCI between November 1, 2012, and March 10, 2015, were analyzed. Laboratory and virtual histology-intravascular ultrasound (VH-IVUS) examinations of culprit lesions were conducted before PCI. Patients were divided according to median apo-C3 into low apo-C3 (≤ 8.5 mg/dL) and high apo-C3 (> 8.5 mg/dL) groups. VH-IVUS data indicated that the percentage of necrotic core volume (%NC) was significantly higher in the high apo-C3 group than in the low apo-C3 group. Moreover, the %NC significantly correlated with the apo-C3 level (R = 0.2109, P = 0.037). Kaplan–Meier curve analysis revealed that freedom from MACEs exhibited a greater decrease in the high apo-C3 group than in the low apo-C3 group, and in the high %NC group than in the low %NC group. Multivariate Cox hazards analysis showed that the %NC and high apo-C3 were independent predictors of 4 year MACEs. Apo-C3 may be a useful marker of future MACEs in patients with SCD after PCI and contribute to %NC growth.https://doi.org/10.1038/s41598-022-18914-1 |
| spellingShingle | Takayuki Ohwada Takayuki Sakamoto Satoshi Suzuki Yukiko Sugawara Kazuya Sakamoto Ayano Ikeda Fumika Haga Tomoki Sato Kazuhiko Nakazato Yasuchika Takeishi Kenichi Watanabe Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events Scientific Reports |
| title | Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events |
| title_full | Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events |
| title_fullStr | Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events |
| title_full_unstemmed | Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events |
| title_short | Apolipoprotein C3 and necrotic core volume are correlated but also associated with future cardiovascular events |
| title_sort | apolipoprotein c3 and necrotic core volume are correlated but also associated with future cardiovascular events |
| url | https://doi.org/10.1038/s41598-022-18914-1 |
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