Kleine–Levin Syndrome: A case report
The Kleine–Levin Syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy. It is characterized by paroxysmal attacks of diurnal excessive sleepiness, associated with one or more symptoms of hyperphagia, hypersexuality, coprolalia and coproprax...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2014-06-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1984006314000285 |
| _version_ | 1797329104488366080 |
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| author | Taís Figueiredo de Araújo Lima Nilce Sanny Costa da Silva Behrens Eduardo Lopes Danielle Pereira Hassana de Almeida Fonseca Paola Oliveira Cavalcanti Marcia Pradella-Hallinan Juliana Castro Sergio Tufik Fernando Morgadinho Santos Coelho |
| author_facet | Taís Figueiredo de Araújo Lima Nilce Sanny Costa da Silva Behrens Eduardo Lopes Danielle Pereira Hassana de Almeida Fonseca Paola Oliveira Cavalcanti Marcia Pradella-Hallinan Juliana Castro Sergio Tufik Fernando Morgadinho Santos Coelho |
| author_sort | Taís Figueiredo de Araújo Lima |
| collection | DOAJ |
| description | The Kleine–Levin Syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy. It is characterized by paroxysmal attacks of diurnal excessive sleepiness, associated with one or more symptoms of hyperphagia, hypersexuality, coprolalia and copropraxia. During crisis intervals, there are no symptoms. This pathology predominantly manifests itself in teenagers, being more frequent among males. The course of this disease is unpredictable, with variable duration and frequency. The most accepted physiopathology is that of a hypothalamic dysfunction, although and recently, there has appeared a hypothesis of a post-infectious autoimmune disorder. These patients show an elevated body mass index, which can predispose to association with comorbidities such as the sleep obstructive apnea syndrome. Treatment involves medications with different effects, but there is no specific and effective therapy. Our article shows a classic case of Kleine–Levin Syndrome associated with sleep obstructive apnea syndrome, a rare association in the literature. |
| first_indexed | 2024-03-08T07:00:24Z |
| format | Article |
| id | doaj.art-0dd0d62f3896400d9b5f1348b26ba62f |
| institution | Directory Open Access Journal |
| issn | 1984-0063 |
| language | English |
| last_indexed | 2024-03-08T07:00:24Z |
| publishDate | 2014-06-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj.art-0dd0d62f3896400d9b5f1348b26ba62f2024-02-03T05:47:50ZengThieme Revinter Publicações Ltda.Sleep Science1984-00632014-06-017212212510.1016/j.slsci.2014.09.001Kleine–Levin Syndrome: A case reportTaís Figueiredo de Araújo Lima0Nilce Sanny Costa da Silva Behrens1Eduardo Lopes2Danielle Pereira3Hassana de Almeida Fonseca4Paola Oliveira Cavalcanti5Marcia Pradella-Hallinan6Juliana Castro7Sergio Tufik8Fernando Morgadinho Santos Coelho9Outpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilOutpatient Facility of Diurnal Excessive Sleepiness, Department of Psychobiology, Federal University of São Paulo, BrazilThe Kleine–Levin Syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy. It is characterized by paroxysmal attacks of diurnal excessive sleepiness, associated with one or more symptoms of hyperphagia, hypersexuality, coprolalia and copropraxia. During crisis intervals, there are no symptoms. This pathology predominantly manifests itself in teenagers, being more frequent among males. The course of this disease is unpredictable, with variable duration and frequency. The most accepted physiopathology is that of a hypothalamic dysfunction, although and recently, there has appeared a hypothesis of a post-infectious autoimmune disorder. These patients show an elevated body mass index, which can predispose to association with comorbidities such as the sleep obstructive apnea syndrome. Treatment involves medications with different effects, but there is no specific and effective therapy. Our article shows a classic case of Kleine–Levin Syndrome associated with sleep obstructive apnea syndrome, a rare association in the literature.http://www.sciencedirect.com/science/article/pii/S1984006314000285Kleine–Levin SyndromeRecurrent hypersleepinessSleep obstructive apnea syndrome |
| spellingShingle | Taís Figueiredo de Araújo Lima Nilce Sanny Costa da Silva Behrens Eduardo Lopes Danielle Pereira Hassana de Almeida Fonseca Paola Oliveira Cavalcanti Marcia Pradella-Hallinan Juliana Castro Sergio Tufik Fernando Morgadinho Santos Coelho Kleine–Levin Syndrome: A case report Sleep Science Kleine–Levin Syndrome Recurrent hypersleepiness Sleep obstructive apnea syndrome |
| title | Kleine–Levin Syndrome: A case report |
| title_full | Kleine–Levin Syndrome: A case report |
| title_fullStr | Kleine–Levin Syndrome: A case report |
| title_full_unstemmed | Kleine–Levin Syndrome: A case report |
| title_short | Kleine–Levin Syndrome: A case report |
| title_sort | kleine levin syndrome a case report |
| topic | Kleine–Levin Syndrome Recurrent hypersleepiness Sleep obstructive apnea syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S1984006314000285 |
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