Potential of Stem Cell-Based Therapy for Ischemic Stroke
Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00034/full |
| _version_ | 1819262632968847360 |
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| author | Hany E. Marei A. Hasan R. Rizzi A. Althani N. Afifi C. Cenciarelli Thomas Caceci Ashfaq Shuaib Ashfaq Shuaib |
| author_facet | Hany E. Marei A. Hasan R. Rizzi A. Althani N. Afifi C. Cenciarelli Thomas Caceci Ashfaq Shuaib Ashfaq Shuaib |
| author_sort | Hany E. Marei |
| collection | DOAJ |
| description | Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed. |
| first_indexed | 2024-12-23T20:00:47Z |
| format | Article |
| id | doaj.art-0dd42c35cced4a86b36d9e7329dcf246 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-23T20:00:47Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0dd42c35cced4a86b36d9e7329dcf2462022-12-21T17:33:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-02-01910.3389/fneur.2018.00034271733Potential of Stem Cell-Based Therapy for Ischemic StrokeHany E. Marei0A. Hasan1R. Rizzi2A. Althani3N. Afifi4C. Cenciarelli5Thomas Caceci6Ashfaq Shuaib7Ashfaq Shuaib8Biomedical Research Center, Qatar University, Doha, QatarDepartment of Mechanical and Industrial Engineering, Qatar University, Doha, QatarInstitute of Cell Biology and Neurobiology (IBCN), Italian National Council of Research (CNR), Rome, ItalyBiomedical Research Center, Qatar University, Doha, QatarQatar Biobank, Doha, QatarInstitute of Translational Pharmacology (CNR), Roma, ItalyBiomedical Sciences, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA, United StatesNeurosciences Institute, Academic Health System, Hamad Medical Corporation, Doha, QatarUniversity of Alberta, Edmonton, AB, CanadaIschemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.http://journal.frontiersin.org/article/10.3389/fneur.2018.00034/fullstem cellmesenchymal stem cellneural stem cellinduced pluripotent stem cellsischemic stroke |
| spellingShingle | Hany E. Marei A. Hasan R. Rizzi A. Althani N. Afifi C. Cenciarelli Thomas Caceci Ashfaq Shuaib Ashfaq Shuaib Potential of Stem Cell-Based Therapy for Ischemic Stroke Frontiers in Neurology stem cell mesenchymal stem cell neural stem cell induced pluripotent stem cells ischemic stroke |
| title | Potential of Stem Cell-Based Therapy for Ischemic Stroke |
| title_full | Potential of Stem Cell-Based Therapy for Ischemic Stroke |
| title_fullStr | Potential of Stem Cell-Based Therapy for Ischemic Stroke |
| title_full_unstemmed | Potential of Stem Cell-Based Therapy for Ischemic Stroke |
| title_short | Potential of Stem Cell-Based Therapy for Ischemic Stroke |
| title_sort | potential of stem cell based therapy for ischemic stroke |
| topic | stem cell mesenchymal stem cell neural stem cell induced pluripotent stem cells ischemic stroke |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00034/full |
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