Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization

Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization

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Summary: Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise cleavage lines by γ-secretase. Of all possible dimer...

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Bibliographic Details
Main Authors: Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Biological Sciences
Biochemistry
Molecular Biology
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310841

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