Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells

Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells

BackgroundEpithelial ovarian cancer (EOC) remains a highly lethal gynecological malignancy. Ascites, an accumulation of peritoneal fluid present in one-third of patients at presentation, is linked to poor prognosis. High levels of regulatory T cells (Tregs) in ascites are correlated with tumor progr...

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Bibliographic Details
Main Authors: Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, Orla M. McNally, Andrew N. Stephens, Michael A. Quinn, Magdalena Plebanski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
epithelial ovarian cancer
malignant ascites
interleukin 6
tumour necrosis factor 2
FoxP3
regulatory T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01482/full

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