Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation

Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation

Placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) family, mediates wound healing and inflammatory responses, exerting an effect on liver fibrosis and angiogenesis; however, the precise mechanism remains unclear. The aims of this study are to identify the role...

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Bibliographic Details
Main Authors: Xi Li, Qianwen Jin, Qunyan Yao, Yi Zhou, Yanting Zou, Zheng Li, Shuncai Zhang, Chuantao Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
placental growth factor
hepatic fibrosis
inflammation
macrophage
Kupffer cells
hepatic stellate cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00801/full

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