Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarctio...
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MDPI AG
2019-05-01
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| Online Access: | https://www.mdpi.com/1420-3049/24/10/1898 |
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| author | Rong-Rong Li Xue-Fang Liu Su-Xiang Feng Sheng-Nan Shu Pei-Yang Wang Na Zhang Jian-Sheng Li Ling-Bo Qu |
| author_facet | Rong-Rong Li Xue-Fang Liu Su-Xiang Feng Sheng-Nan Shu Pei-Yang Wang Na Zhang Jian-Sheng Li Ling-Bo Qu |
| author_sort | Rong-Rong Li |
| collection | DOAJ |
| description | (1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations at different time points, and DAS software was used to calculate pharmacokinetic parameters in a noncompartmental model. (3) Results: The results showed that the pharmacodynamics and pharmacokinetics of one of the five anthraquinone aglycones could be modified by the other four anthraquinones, and the degree of interaction between different anthraquinones was different. The chrysophanol group showed the greatest reduction in pharmacodynamic indicators comparing with other four groups where the rats were administered one of the five anthraquinones, and there was no significant difference between the nimodipine group. While the Aloe-emodin + Physcion group showed the most obvious anti-ischemic effect among the groups where the subjects were administered two of the five anthraquinones simultaneously. Emodin, rhein, chrysophanol, and physcion all increase plasma exposure levels of aloe-emodin, while aloe-emodin lower their plasma exposure levels. (4) Conclusions: This experiment provides a certain preclinical basis for the study of anthraquinone aglycones against cerebral ischemia and a theoretical basis for the study of the mechanism of interaction between anthraquinones. |
| first_indexed | 2024-12-14T19:00:01Z |
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| last_indexed | 2024-12-14T19:00:01Z |
| publishDate | 2019-05-01 |
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| series | Molecules |
| spelling | doaj.art-0dd60cbf89994610acbbe5600f6d6fc52022-12-21T22:50:58ZengMDPI AGMolecules1420-30492019-05-012410189810.3390/molecules24101898molecules24101898Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral IschemiaRong-Rong Li0Xue-Fang Liu1Su-Xiang Feng2Sheng-Nan Shu3Pei-Yang Wang4Na Zhang5Jian-Sheng Li6Ling-Bo Qu7College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, ChinaCollege of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain water content, and cerebral infarction area; UPLC-MS/MS was used in pharmacokinetic studies to detect plasma concentrations at different time points, and DAS software was used to calculate pharmacokinetic parameters in a noncompartmental model. (3) Results: The results showed that the pharmacodynamics and pharmacokinetics of one of the five anthraquinone aglycones could be modified by the other four anthraquinones, and the degree of interaction between different anthraquinones was different. The chrysophanol group showed the greatest reduction in pharmacodynamic indicators comparing with other four groups where the rats were administered one of the five anthraquinones, and there was no significant difference between the nimodipine group. While the Aloe-emodin + Physcion group showed the most obvious anti-ischemic effect among the groups where the subjects were administered two of the five anthraquinones simultaneously. Emodin, rhein, chrysophanol, and physcion all increase plasma exposure levels of aloe-emodin, while aloe-emodin lower their plasma exposure levels. (4) Conclusions: This experiment provides a certain preclinical basis for the study of anthraquinone aglycones against cerebral ischemia and a theoretical basis for the study of the mechanism of interaction between anthraquinones.https://www.mdpi.com/1420-3049/24/10/1898anthraquinonespharmacodynamicspharmacodynamicspharmacokineticsinteraction |
| spellingShingle | Rong-Rong Li Xue-Fang Liu Su-Xiang Feng Sheng-Nan Shu Pei-Yang Wang Na Zhang Jian-Sheng Li Ling-Bo Qu Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia Molecules anthraquinones pharmacodynamics pharmacodynamics pharmacokinetics interaction |
| title | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia |
| title_full | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia |
| title_fullStr | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia |
| title_full_unstemmed | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia |
| title_short | Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia |
| title_sort | pharmacodynamics of five anthraquinones aloe emodin emodin rhein chysophanol and physcion and reciprocal pharmacokinetic interaction in rats with cerebral ischemia |
| topic | anthraquinones pharmacodynamics pharmacodynamics pharmacokinetics interaction |
| url | https://www.mdpi.com/1420-3049/24/10/1898 |
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