African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus <i>Asfivirus</i> and <i>Asfarviridae</i> African suids family. The disease is among the most devastating pig diseases worldwide including...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/11/2285 |
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| author | Emma P. Njau Eunice M. Machuka Sarah Cleaveland Gabriel M. Shirima Lughano J. Kusiluka Edward A. Okoth Roger Pelle |
| author_facet | Emma P. Njau Eunice M. Machuka Sarah Cleaveland Gabriel M. Shirima Lughano J. Kusiluka Edward A. Okoth Roger Pelle |
| author_sort | Emma P. Njau |
| collection | DOAJ |
| description | African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus <i>Asfivirus</i> and <i>Asfarviridae</i> African suids family. The disease is among the most devastating pig diseases worldwide including Africa. Although the disease was first reported in the 19th century, it has continued to spread in Africa and other parts of the world. Globally, the rising demand for pork and concomitant increase in transboundary movements of pigs and pork products is likely to increase the risk of transmission and spread of ASF and pose a major challenge to the pig industry. Different genotypes of the ASF virus (ASFV) with varying virulence have been associated with different outbreaks in several countries in sub-Saharan Africa (SSA) and worldwide, and understanding genotype circulation will be important for ASF prevention and control strategies. ASFV genotypes unique to Africa have also been reported in SSA. This review briefly recounts the biology, genomics and genotyping of ASFV and provides an account of the different genotypes circulating in SSA. The review also highlights prevention, control and progress on vaccine development and identifies gaps in knowledge of ASFV genotype circulation in SSA that need to be addressed. |
| first_indexed | 2024-03-10T04:58:49Z |
| format | Article |
| id | doaj.art-0dd82b6218d74daba5e956f7ba8b28a4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T04:58:49Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-0dd82b6218d74daba5e956f7ba8b28a42023-11-23T01:58:10ZengMDPI AGViruses1999-49152021-11-011311228510.3390/v13112285African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan AfricaEmma P. Njau0Eunice M. Machuka1Sarah Cleaveland2Gabriel M. Shirima3Lughano J. Kusiluka4Edward A. Okoth5Roger Pelle6Biosciences Eastern and Central Africa—International Livestock Research Institute Hub, P.O. Box 30709, Nairobi 00100, KenyaBiosciences Eastern and Central Africa—International Livestock Research Institute Hub, P.O. Box 30709, Nairobi 00100, KenyaNelson Mandela African Institution of Science and Technology, Arusha P.O. Box 447, TanzaniaNelson Mandela African Institution of Science and Technology, Arusha P.O. Box 447, TanzaniaNelson Mandela African Institution of Science and Technology, Arusha P.O. Box 447, TanzaniaBiosciences Eastern and Central Africa—International Livestock Research Institute Hub, P.O. Box 30709, Nairobi 00100, KenyaBiosciences Eastern and Central Africa—International Livestock Research Institute Hub, P.O. Box 30709, Nairobi 00100, KenyaAfrican swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus <i>Asfivirus</i> and <i>Asfarviridae</i> African suids family. The disease is among the most devastating pig diseases worldwide including Africa. Although the disease was first reported in the 19th century, it has continued to spread in Africa and other parts of the world. Globally, the rising demand for pork and concomitant increase in transboundary movements of pigs and pork products is likely to increase the risk of transmission and spread of ASF and pose a major challenge to the pig industry. Different genotypes of the ASF virus (ASFV) with varying virulence have been associated with different outbreaks in several countries in sub-Saharan Africa (SSA) and worldwide, and understanding genotype circulation will be important for ASF prevention and control strategies. ASFV genotypes unique to Africa have also been reported in SSA. This review briefly recounts the biology, genomics and genotyping of ASFV and provides an account of the different genotypes circulating in SSA. The review also highlights prevention, control and progress on vaccine development and identifies gaps in knowledge of ASFV genotype circulation in SSA that need to be addressed.https://www.mdpi.com/1999-4915/13/11/2285arbovirusAfrican swine fevervirusswinepigsAfrica |
| spellingShingle | Emma P. Njau Eunice M. Machuka Sarah Cleaveland Gabriel M. Shirima Lughano J. Kusiluka Edward A. Okoth Roger Pelle African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa Viruses arbovirus African swine fever virus swine pigs Africa |
| title | African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa |
| title_full | African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa |
| title_fullStr | African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa |
| title_full_unstemmed | African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa |
| title_short | African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa |
| title_sort | african swine fever virus asfv biology genomics and genotypes circulating in sub saharan africa |
| topic | arbovirus African swine fever virus swine pigs Africa |
| url | https://www.mdpi.com/1999-4915/13/11/2285 |
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