Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions
Abstract Background Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high and the survival rate was low. Over the years, accumulating evidence h...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03325-4 |
| _version_ | 1797827619501113344 |
|---|---|
| author | Sijia Li Lihua Dong Zhenyu Pan Guozi Yang |
| author_facet | Sijia Li Lihua Dong Zhenyu Pan Guozi Yang |
| author_sort | Sijia Li |
| collection | DOAJ |
| description | Abstract Background Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high and the survival rate was low. Over the years, accumulating evidence has shown that the subventricular zone has an important role in the recurrence and treatment resistance of glioblastoma. The human adult subventricular zone contains neural stem cells and glioma stem cells that are probably a part of reason for therapy resistance and recurrence of glioblastoma. Main body Over the years, both bench and bedside evidences strongly support the view that the presence of neural stem cells and glioma stem cells in the subventricular zone may be the crucial factor of recurrence of glioblastoma after conventional therapy. It emphasizes the necessity to explore new therapy strategies with the aim to target subventricular zone to eradicate neural stem cells or glioma stem cells. In this review, we summarize the recent preclinical and clinical advances in targeting neural stem cells in the subventricular zone for glioblastoma treatment, and clarify the prospects and challenges in clinical application. Conclusions Although there remain unresolved issues, current advances provide us with a lot of evidence that targeting the neural stem cells and glioma stem cells in subventricular zone may have the potential to solve the dilemma of glioblastoma recurrence and treatment resistance. |
| first_indexed | 2024-04-09T12:51:14Z |
| format | Article |
| id | doaj.art-0dd895950d6f4af5b688653ae6a7623e |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T12:51:14Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-0dd895950d6f4af5b688653ae6a7623e2023-05-14T11:10:28ZengBMCStem Cell Research & Therapy1757-65122023-05-0114111110.1186/s13287-023-03325-4Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventionsSijia Li0Lihua Dong1Zhenyu Pan2Guozi Yang3Jilin Provincial Key Laboratory of Radiation Oncology and Therapy, Department of Radiation Oncology and Therapy, The First Hospital of Jilin UniversityJilin Provincial Key Laboratory of Radiation Oncology and Therapy, Department of Radiation Oncology and Therapy, The First Hospital of Jilin UniversityDepartment of Radiation Oncology, Huizhou Third People’s Hospital, Guangzhou Medical UniversityJilin Provincial Key Laboratory of Radiation Oncology and Therapy, Department of Radiation Oncology and Therapy, The First Hospital of Jilin UniversityAbstract Background Glioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with chemoradiotherapy, did not change the fact that the recurrence rate was high and the survival rate was low. Over the years, accumulating evidence has shown that the subventricular zone has an important role in the recurrence and treatment resistance of glioblastoma. The human adult subventricular zone contains neural stem cells and glioma stem cells that are probably a part of reason for therapy resistance and recurrence of glioblastoma. Main body Over the years, both bench and bedside evidences strongly support the view that the presence of neural stem cells and glioma stem cells in the subventricular zone may be the crucial factor of recurrence of glioblastoma after conventional therapy. It emphasizes the necessity to explore new therapy strategies with the aim to target subventricular zone to eradicate neural stem cells or glioma stem cells. In this review, we summarize the recent preclinical and clinical advances in targeting neural stem cells in the subventricular zone for glioblastoma treatment, and clarify the prospects and challenges in clinical application. Conclusions Although there remain unresolved issues, current advances provide us with a lot of evidence that targeting the neural stem cells and glioma stem cells in subventricular zone may have the potential to solve the dilemma of glioblastoma recurrence and treatment resistance.https://doi.org/10.1186/s13287-023-03325-4GlioblastomaSubventricular zoneNeural stem cellsGlioma stem cellsRadiation |
| spellingShingle | Sijia Li Lihua Dong Zhenyu Pan Guozi Yang Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions Stem Cell Research & Therapy Glioblastoma Subventricular zone Neural stem cells Glioma stem cells Radiation |
| title | Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions |
| title_full | Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions |
| title_fullStr | Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions |
| title_full_unstemmed | Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions |
| title_short | Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions |
| title_sort | targeting the neural stem cells in subventricular zone for the treatment of glioblastoma an update from preclinical evidence to clinical interventions |
| topic | Glioblastoma Subventricular zone Neural stem cells Glioma stem cells Radiation |
| url | https://doi.org/10.1186/s13287-023-03325-4 |
| work_keys_str_mv | AT sijiali targetingtheneuralstemcellsinsubventricularzoneforthetreatmentofglioblastomaanupdatefrompreclinicalevidencetoclinicalinterventions AT lihuadong targetingtheneuralstemcellsinsubventricularzoneforthetreatmentofglioblastomaanupdatefrompreclinicalevidencetoclinicalinterventions AT zhenyupan targetingtheneuralstemcellsinsubventricularzoneforthetreatmentofglioblastomaanupdatefrompreclinicalevidencetoclinicalinterventions AT guoziyang targetingtheneuralstemcellsinsubventricularzoneforthetreatmentofglioblastomaanupdatefrompreclinicalevidencetoclinicalinterventions |