Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue
Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381227/full |
| _version_ | 1797224378529742848 |
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| author | Kaile Ma Yanjiao Zhang Jingyi Zhao Lijuan Zhou Min Li |
| author_facet | Kaile Ma Yanjiao Zhang Jingyi Zhao Lijuan Zhou Min Li |
| author_sort | Kaile Ma |
| collection | DOAJ |
| description | Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic reticulum stress (ERS). ERS modulates metabolism, insulin signaling, inflammation, as well as cell proliferation and death through the unfolded protein response (UPR) pathway. Serving as a crucial nexus, ERS bridges the functionality of adipose tissue and the inflammatory response. In this review, we comprehensively elucidate the mechanisms by which ERS impacts adipose tissue function and inflammation in obesity, aiming to offer insights into targeting ERS for ameliorating metabolic dysregulation in obesity-associated chronic diseases such as hyperlipidemia, hypertension, fatty liver, and type 2 diabetes. |
| first_indexed | 2024-04-24T13:52:10Z |
| format | Article |
| id | doaj.art-0dda3cc577b849c9a5717af789728622 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T13:52:10Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0dda3cc577b849c9a5717af7897286222024-04-04T04:33:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13812271381227Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissueKaile MaYanjiao ZhangJingyi ZhaoLijuan ZhouMin LiObesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within the context of obesity, lipid metabolism, adipose tissue formation, and inflammation are intricately linked to endoplasmic reticulum stress (ERS). ERS modulates metabolism, insulin signaling, inflammation, as well as cell proliferation and death through the unfolded protein response (UPR) pathway. Serving as a crucial nexus, ERS bridges the functionality of adipose tissue and the inflammatory response. In this review, we comprehensively elucidate the mechanisms by which ERS impacts adipose tissue function and inflammation in obesity, aiming to offer insights into targeting ERS for ameliorating metabolic dysregulation in obesity-associated chronic diseases such as hyperlipidemia, hypertension, fatty liver, and type 2 diabetes.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381227/fullendoplasmic reticulum stressadipose tissueobesityinflammationmetabolic disorder |
| spellingShingle | Kaile Ma Yanjiao Zhang Jingyi Zhao Lijuan Zhou Min Li Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue Frontiers in Immunology endoplasmic reticulum stress adipose tissue obesity inflammation metabolic disorder |
| title | Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue |
| title_full | Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue |
| title_fullStr | Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue |
| title_full_unstemmed | Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue |
| title_short | Endoplasmic reticulum stress: bridging inflammation and obesity-associated adipose tissue |
| title_sort | endoplasmic reticulum stress bridging inflammation and obesity associated adipose tissue |
| topic | endoplasmic reticulum stress adipose tissue obesity inflammation metabolic disorder |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1381227/full |
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