Absence of relevant QT interval prolongation in not critically ill COVID-19 patients
Abstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-78360-9 |
| _version_ | 1818346603346395136 |
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| author | Juan Jiménez-Jáimez Rosa Macías-Ruiz Francisco Bermúdez-Jiménez Ricardo Rubini-Costa Jessica Ramírez-Taboada Paula Isabel García Flores Laura Gallo-Padilla Juan Diego Mediavilla García Concepción Morales García Sara Moreno Suárez Celia Fignani Molina Miguel Álvarez López Luis Tercedor |
| author_facet | Juan Jiménez-Jáimez Rosa Macías-Ruiz Francisco Bermúdez-Jiménez Ricardo Rubini-Costa Jessica Ramírez-Taboada Paula Isabel García Flores Laura Gallo-Padilla Juan Diego Mediavilla García Concepción Morales García Sara Moreno Suárez Celia Fignani Molina Miguel Álvarez López Luis Tercedor |
| author_sort | Juan Jiménez-Jáimez |
| collection | DOAJ |
| description | Abstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill and not monitored cohort of patients. We evaluated admitted and ambulatory patients with COVID-19 patients with 12 lead electrocardiogram at 48 h after treatment initiation. Other clinical and analytical variables were collected. Statistical analysis was performed to assess the magnitude of the QT interval prolongation under treatment and to identify clinical, analytical and electrocardiographic risk markers of QT prolongation independent predictors. We included 219 patients (mean age of 63.6 ± 17.4 years, 48.9% were women and 16.4% were outpatients. The median baseline QTc was 416 ms (IQR 404–433), and after treatment QTc was prolonged to 423 ms (405–438) (P < 0.001), with an average increase of 1.8%. Most of the patients presented a normal QTc under treatment, with only 31 cases (14.1%) showing a QTc interval > 460 ms, and just one case with QTc > 500 ms. Advanced age, longer QTc basal at the basal ECG and lower potassium levels were independent predictors of QTc interval prolongation. Ambulatory and not critically ill patients with COVID-19 treated with hydroxychloroquine, azithromycin and/or antiretrovirals develop a significant, but not relevant, QT interval prolongation. |
| first_indexed | 2024-12-13T17:20:53Z |
| format | Article |
| id | doaj.art-0ddaaea59a564eee8cd88c0cb2f77917 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:20:53Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-0ddaaea59a564eee8cd88c0cb2f779172022-12-21T23:37:19ZengNature PortfolioScientific Reports2045-23222020-12-011011810.1038/s41598-020-78360-9Absence of relevant QT interval prolongation in not critically ill COVID-19 patientsJuan Jiménez-Jáimez0Rosa Macías-Ruiz1Francisco Bermúdez-Jiménez2Ricardo Rubini-Costa3Jessica Ramírez-Taboada4Paula Isabel García Flores5Laura Gallo-Padilla6Juan Diego Mediavilla García7Concepción Morales García8Sara Moreno Suárez9Celia Fignani Molina10Miguel Álvarez López11Luis Tercedor12Cardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalCardiology Department, Virgen de Las Nieves University HospitalAbstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill and not monitored cohort of patients. We evaluated admitted and ambulatory patients with COVID-19 patients with 12 lead electrocardiogram at 48 h after treatment initiation. Other clinical and analytical variables were collected. Statistical analysis was performed to assess the magnitude of the QT interval prolongation under treatment and to identify clinical, analytical and electrocardiographic risk markers of QT prolongation independent predictors. We included 219 patients (mean age of 63.6 ± 17.4 years, 48.9% were women and 16.4% were outpatients. The median baseline QTc was 416 ms (IQR 404–433), and after treatment QTc was prolonged to 423 ms (405–438) (P < 0.001), with an average increase of 1.8%. Most of the patients presented a normal QTc under treatment, with only 31 cases (14.1%) showing a QTc interval > 460 ms, and just one case with QTc > 500 ms. Advanced age, longer QTc basal at the basal ECG and lower potassium levels were independent predictors of QTc interval prolongation. Ambulatory and not critically ill patients with COVID-19 treated with hydroxychloroquine, azithromycin and/or antiretrovirals develop a significant, but not relevant, QT interval prolongation.https://doi.org/10.1038/s41598-020-78360-9 |
| spellingShingle | Juan Jiménez-Jáimez Rosa Macías-Ruiz Francisco Bermúdez-Jiménez Ricardo Rubini-Costa Jessica Ramírez-Taboada Paula Isabel García Flores Laura Gallo-Padilla Juan Diego Mediavilla García Concepción Morales García Sara Moreno Suárez Celia Fignani Molina Miguel Álvarez López Luis Tercedor Absence of relevant QT interval prolongation in not critically ill COVID-19 patients Scientific Reports |
| title | Absence of relevant QT interval prolongation in not critically ill COVID-19 patients |
| title_full | Absence of relevant QT interval prolongation in not critically ill COVID-19 patients |
| title_fullStr | Absence of relevant QT interval prolongation in not critically ill COVID-19 patients |
| title_full_unstemmed | Absence of relevant QT interval prolongation in not critically ill COVID-19 patients |
| title_short | Absence of relevant QT interval prolongation in not critically ill COVID-19 patients |
| title_sort | absence of relevant qt interval prolongation in not critically ill covid 19 patients |
| url | https://doi.org/10.1038/s41598-020-78360-9 |
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