Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/19/12/20391 |
| _version_ | 1818613825222475776 |
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| author | Concetta Imperatore Anna Aiello Filomena D'Aniello Maria Senese Marialuisa Menna |
| author_facet | Concetta Imperatore Anna Aiello Filomena D'Aniello Maria Senese Marialuisa Menna |
| author_sort | Concetta Imperatore |
| collection | DOAJ |
| description | The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery. |
| first_indexed | 2024-12-16T16:08:16Z |
| format | Article |
| id | doaj.art-0ddac48a9a844f34ae15851564481af8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T16:08:16Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-0ddac48a9a844f34ae15851564481af82022-12-21T22:25:17ZengMDPI AGMolecules1420-30492014-12-011912203912042310.3390/molecules191220391molecules191220391Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and DevelopmentConcetta Imperatore0Anna Aiello1Filomena D'Aniello2Maria Senese3Marialuisa Menna4The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, ItalyThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, ItalyThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, ItalyThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, ItalyThe NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, ItalyThe present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.http://www.mdpi.com/1420-3049/19/12/20391alkaloidsmarine invertebratesanticancernatural productsdrug discovery |
| spellingShingle | Concetta Imperatore Anna Aiello Filomena D'Aniello Maria Senese Marialuisa Menna Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development Molecules alkaloids marine invertebrates anticancer natural products drug discovery |
| title | Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development |
| title_full | Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development |
| title_fullStr | Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development |
| title_full_unstemmed | Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development |
| title_short | Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development |
| title_sort | alkaloids from marine invertebrates as important leads for anticancer drugs discovery and development |
| topic | alkaloids marine invertebrates anticancer natural products drug discovery |
| url | http://www.mdpi.com/1420-3049/19/12/20391 |
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