Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion

Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion

Abstract Background Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously observed elevated expression of uPAR at the tumour-stroma interface in...

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Bibliographic Details
Main Authors: Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen, Gunbjorg Svineng
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Cancer
Subjects:
Urokinase plasminogen activator receptor (uPAR)
Urokinase receptor
Transforming growth factor-beta1 (TGF-β1)
Plasminogen
Plasmin
Cancer
Online Access:http://link.springer.com/article/10.1186/s12885-017-3349-7

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