Mechanism of action of nadofaragene firadenovec-vncg

Mechanism of action of nadofaragene firadenovec-vncg

Effective bladder-preserving therapeutic options are needed for patients with bacillus Calmette-Guérin unresponsive non–muscle-invasive bladder cancer. Nadofaragene firadenovec-vncg (Adstiladrin®) was approved by the US Food and Drug Administration as the first gene therapy in urology and the first...

Full description

Bibliographic Details
Main Authors:	Vikram M. Narayan, Joshua J. Meeks, Jørn S. Jakobsen, Neal D. Shore, Grannum R. Sant, Badrinath R. Konety
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Oncology
Subjects:	adenoviral-mediated interferon delivery Adstiladrin BCG-unresponsive nadofaragene firadenovec-vncg non-muscle-invasive bladder cancer Syn3
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1359725/full

Similar Items

Nadofaragene firadenovec: a breakthrough in the field of bladder oncology
by: Abdullah Nadeem, et al.
Published: (2023-09-01)

Clinical use of nadofaragene firadenovec-vncg
by: Badrinath R. Konety, et al.
Published: (2024-09-01)

Interferon gene therapy with nadofaragene firadenovec for bladder cancer: from bench to approval
by: Alberto Martini, et al.
Published: (2023-08-01)

Patterns of treatment of high-risk BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) patients among Arab urologists
by: Mohamad Moussa, et al.
Published: (2024-03-01)

Systematic Review and Meta-Analysis of Response Rates in BCG-unresponsive Non–Muscle-Invasive Bladder Cancer: a Consensus Statement From the International Bladder Cancer Group
by: Kyle M. Rose, et al.
Published: (2022-09-01)

Oncolytic and immunotherapeutic CG0070 adenovirus for high-risk bacillus calmette-guerin unresponsive bladder cancer
by: Evan Austin, et al.
Published: (2021-12-01)

Novel Therapeutic Strategies for BCG-unresponsive Non-muscle Invasive Bladder Cancer
by: Peng Zhang, et al.
Published: (2022-12-01)

High-Throughput Screening for the Prevalence of Neutralizing Antibodies against Human Adenovirus Serotype 5
by: Jochen M. Wettengel, et al.
Published: (2024-02-01)

Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model
by: Alexis R. Steinmetz, et al.
Published: (2024-11-01)

Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses
by: Wen-Chien Wang, et al.
Published: (2025-01-01)

Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines
by: Ekramy E. Sayedahmed, et al.
Published: (2020-10-01)

Epidemic Keratoconjunctivitis in India: Trend Analysis and Implications for Viral Outbreaks
by: Anthony V Das, et al.
Published: (2020-01-01)

A Phase 1b Clinical Study of Intravesical Photodynamic Therapy in Patients with Bacillus Calmette-Guérin–unresponsive Non–muscle-invasive Bladder Cancer
by: Girish S. Kulkarni, et al.
Published: (2022-07-01)

Urovysion™ testing can lead to early identification of intravesical therapy failure in patients with high risk non-muscle invasive bladder cancer
by: Jared M. Whitson, et al.
Published: (2009-12-01)

FEATURES OF CLINICAL COURSE AND THERAPY OF COMBINED CORNEAL LESION AS A RESULT CYTOMEGALOVIRAL KERATOIRIDOCYCLITIS AND ADENOVIRAL KERATOCONJUNCTIVITIS
by: O. A. Vasilyeva, et al.
Published: (2015-10-01)

PECULIARITIES OF THE COURSE OF THE ADENOVIRAL OPHTALMOINFECTION IN PATIENTS WITH SYSTEMIC ALLERGY
by: E. V. YANI, et al.
Published: (2016-12-01)

Factors Which Contribute to the Immunogenicity of Non-replicating Adenoviral Vectored Vaccines
by: Lynda Coughlan
Published: (2020-05-01)

Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector
by: Ekramy E. Sayedahmed, et al.
Published: (2023-11-01)

The Glasgow Coma Scale and Full Outline of Unresponsiveness score evaluation to predict patient outcomes with neurological illnesses in intensive care units in the West Bank: a prospective cross-sectional study
by: Wourod Mahmoud Omar, et al.
Published: (2024-08-01)

The effectiveness of Interferon-Ophthalmo, an antiviral and immunotropic drug, in the treatment of adenoviral ophthalmic infections
by: E. V. Yani, et al.
Published: (2023-03-01)

Performance Analysis of Synchronous Reluctance Motor with Limited Amount of Permanent Magnet
by: Duc-Kien Ngo, et al.
Published: (2019-09-01)

Migraine and Cerebellar Ataxia
by: J Gordon Millichap
Published: (1990-09-01)

Natural desiccated thyroid for the treatment of hypothyroidism?
by: Adrian H. Heald, et al.
Published: (2024-01-01)

Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches
by: Carmine D'Amico, et al.
Published: (2025-03-01)

Adenovirus as a Vector and Oncolytic Virus
by: Wataru Matsunaga, et al.
Published: (2023-06-01)

Epidemiology, clinical presentation, and respiratory sequelae of severe adenoviral pneumonia in children admitted in a tertiary care pediatric intensive care unit from Eastern India: A single-center observational study
by: Argha Rajbanshi, et al.
Published: (2022-01-01)

Pathogenesis and management of adenoviral keratoconjunctivitis
by: Chigbu DI, et al.
Published: (2018-07-01)

Comparison of Efficacy of Two Different Topical 0.05% Cyclosporine A Formulations in the Treatment of Adenoviral Keratoconjunctivitis-Related Subepithelial Infiltrates
by: Betül N. Bayraktutar, et al.
Published: (2016-03-01)

Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy
by: Wen-Chien Wang, et al.
Published: (2022-12-01)

Performance Analysis of Permanent Magnet Motors for Electric Vehicles (EV) Traction Considering Driving Cycles
by: Thanh Anh Huynh, et al.
Published: (2018-05-01)

After 100 Years of BCG Immunization against Tuberculosis, What Is New and Still Outstanding for This Vaccine?
by: Mario Alberto Flores-Valdez
Published: (2021-12-01)

Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model
by: Emre Kul, et al.
Published: (2024-06-01)

EEG signature of near-death-like experiences during syncope-induced periods of unresponsiveness
by: Charlotte Martial, et al.
Published: (2024-09-01)

Regulatory T cell activity and signs of T cell unresponsiveness in bovine paratuberculosis
by: Jonathan A Roussey, et al.
Published: (2014-10-01)

Onychomycosis unresponsive to antifungals: Etiology and treatment with a new direct technique
by: Fatma Gülru Erdogan, et al.
Published: (2019-01-01)

Features of a clinical course of the acute respiratory diseases caused by adenoviruses of epidemic significant serotypes
by: N. I. L`vov, et al.
Published: (2014-09-01)

In vitro immune evaluation of adenoviral vector-based platform for infectious diseases
by: Joanna Baran, et al.
Published: (2023-12-01)

PREVENTION OF ADENOVIRAL EYE INFECTION - REVIEW
by: Katarina Mirjane Janicijevic, et al.
Published: (2017-04-01)

Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner
by: Mareike D. Maler, et al.
Published: (2024-03-01)

An Adenoviral Vector as a Versatile Tool for Delivery and Expression of miRNAs
by: Jonas Scholz, et al.
Published: (2022-09-01)