TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

Tumor progression locus 2 (TPL2) (MAP3K8) is a central signaling node in the inflammatory response of peripheral immune cells. We find that TPL2 kinase activity modulates microglial cytokine release and is required for microglia-mediated neuron death in vitro. In acute in vivo neuroinflammation sett...

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Bibliographic Details
Main Authors: Yuanyuan Wang, Tiffany Wu, Ming-Chi Tsai, Mitchell G Rezzonico, Alyaa M Abdel-Haleem, Luke Xie, Vineela D Gandham, Hai Ngu, Kimberly Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A Friedman, Morgan Sheng, Jesse E Hanson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
TPL2
neurodegeneration
neuroinflammation
microglia
T-cell
single-cell RNA sequencing
Online Access:https://elifesciences.org/articles/83451

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