Antithrombotic drugs with adjuvant action against COVID-19

Waiting for the vaccine and/or the best antiviral treatment for coronavirus infection disease 2019 (COVID-19), after its outbreak in China at the beginning of 2020 and its viral diffusion around the world in the following weeks, several drugs have been suggested for their potential adjuvant support...

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Main Authors: Pierpaolo Di Micco, Gianluca Di Micco, Vincenzo Russo, Andrea Fontanella
Format: Article
Language:English
Published: PAGEPress Publications 2020-12-01
Series:Italian Journal of Medicine
Subjects:
Online Access:https://www.italjmed.org/index.php/ijm/article/view/1348
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author Pierpaolo Di Micco
Gianluca Di Micco
Vincenzo Russo
Andrea Fontanella
author_facet Pierpaolo Di Micco
Gianluca Di Micco
Vincenzo Russo
Andrea Fontanella
author_sort Pierpaolo Di Micco
collection DOAJ
description Waiting for the vaccine and/or the best antiviral treatment for coronavirus infection disease 2019 (COVID-19), after its outbreak in China at the beginning of 2020 and its viral diffusion around the world in the following weeks, several drugs have been suggested for their potential adjuvant support against infection. Several drugs have been suggested to have a potential ancillary antiviral role. Circulating proteins, in particular proteases and peptidases regulated by drug functions, may interact with well-known drugs like anticoagulants, antihypertensives, antiserotoninergics, and so also with viral proteases. We here report a brief list of these drugs (i.e., heparinoids, flavonoids, antiplatelets, anticoagulants) that may interact with COVID-19.
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spelling doaj.art-0de4721341694dd9ac9dfae9b55a5a2a2023-12-02T09:33:56ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522020-12-0114410.4081/itjm.2020.1348Antithrombotic drugs with adjuvant action against COVID-19Pierpaolo Di Micco0Gianluca Di Micco1Vincenzo Russo2Andrea Fontanella3Internal Medicine Department, Emergency Room Unit, Fatebenefratelli Hospital, NaplesDiagnostic Center Varelli, NaplesDepartment of Translational Medical Sciences, University of Campania Luigi Vanvitelli - Monaldi Hospital, NaplesInternal Medicine Department, Emergency Room Unit, Fatebenefratelli Hospital, NaplesWaiting for the vaccine and/or the best antiviral treatment for coronavirus infection disease 2019 (COVID-19), after its outbreak in China at the beginning of 2020 and its viral diffusion around the world in the following weeks, several drugs have been suggested for their potential adjuvant support against infection. Several drugs have been suggested to have a potential ancillary antiviral role. Circulating proteins, in particular proteases and peptidases regulated by drug functions, may interact with well-known drugs like anticoagulants, antihypertensives, antiserotoninergics, and so also with viral proteases. We here report a brief list of these drugs (i.e., heparinoids, flavonoids, antiplatelets, anticoagulants) that may interact with COVID-19.https://www.italjmed.org/index.php/ijm/article/view/1348COVID-19flavonoidsheparinanticoagulantsfondaparinux.
spellingShingle Pierpaolo Di Micco
Gianluca Di Micco
Vincenzo Russo
Andrea Fontanella
Antithrombotic drugs with adjuvant action against COVID-19
Italian Journal of Medicine
COVID-19
flavonoids
heparin
anticoagulants
fondaparinux.
title Antithrombotic drugs with adjuvant action against COVID-19
title_full Antithrombotic drugs with adjuvant action against COVID-19
title_fullStr Antithrombotic drugs with adjuvant action against COVID-19
title_full_unstemmed Antithrombotic drugs with adjuvant action against COVID-19
title_short Antithrombotic drugs with adjuvant action against COVID-19
title_sort antithrombotic drugs with adjuvant action against covid 19
topic COVID-19
flavonoids
heparin
anticoagulants
fondaparinux.
url https://www.italjmed.org/index.php/ijm/article/view/1348
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AT andreafontanella antithromboticdrugswithadjuvantactionagainstcovid19